| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T121 |
0-169 |
Sentence |
denotes |
In summary, we found injury of the eGC and speculate that this might represent a potentially critical hallmark of later widespread endothelial injury in severe COVID-19. |
| T122 |
170-263 |
Sentence |
denotes |
Reduced eGC thickness was visualized in vivo by employing sublingual SDF imaging in patients. |
| T123 |
264-515 |
Sentence |
denotes |
At the same time, increased syndecan-1 and sTie-2 concentrations in the blood of these patients indicated shedding of important endothelial transmembrane proteins responsible for building (5) and maintaining (6) the structure of the eGC, respectively. |
| T124 |
516-653 |
Sentence |
denotes |
Interestingly, eGC shedding could be reproduced when patient blood was transferred ex vivo into an endothelial microcapillary chip model. |
| T125 |
654-886 |
Sentence |
denotes |
Although Hpa-1 and its enzymatic activity (primarily responsible for HS degradation) (7) was found to be normal, Hpa-2, a protein that has been described as a protective antagonist of Hpa-1 (8, 9), was severely depleted in COVID-19. |
| T126 |
887-1007 |
Sentence |
denotes |
Importantly, degradation of the eGC after perfusion with COVID-19 serum could be attenuated in ECs overexpressing Hpa-2. |
| T127 |
1008-1199 |
Sentence |
denotes |
We therefore postulate that acquired Hpa-2 deficiency might represent a potential mechanism of injury to the eGC, which could later progress to widespread endothelial dysfunction in COVID-19. |
