| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T389 |
0-88 |
Sentence |
denotes |
ACE2 shedding is an additional mechanism contributing to inflammation (Fu et al., 2020). |
| T390 |
89-342 |
Sentence |
denotes |
ACE2 shedding consists in proteolytic cleavage of the protein ectodomain and leads to the release of enzymatically active soluble ACE2 (sACE), whose action is not completely understood, but might enhance the pro-inflammatory response (Guy et al., 2005). |
| T391 |
343-558 |
Sentence |
denotes |
ADAM 17 and disintegrin are able to shed not only TNFα but also a variety of membrane-anchored enzymes, including ACE2 (Black et al., 1997; Palau et al., 2020), as demonstrated by Lambert in 2005 (Guy et al., 2005). |
| T392 |
559-875 |
Sentence |
denotes |
In their experiment, human embryonic kidney cells (HEK293) expressing human ACE2 (HEK-ACE2) were treated with phorbol myristate acetate stimulation and the production of a polypeptide of 105 kDa was demonstrated by western blot analysis, suggesting the occurrence of a proteolytic shedding in the ectodomain of ACE2. |
| T393 |
876-1096 |
Sentence |
denotes |
Subsequently, they demonstrated that the cleavage was performed by ADAM17, incubating cells with a specific hydroxamic acid-based metalloproteinase inhibitor, namely TAPI-1 (TNFα protease inhibitor 1) (Guy et al., 2005). |
