| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T373 |
0-118 |
Sentence |
denotes |
The molecular mechanisms involved in the cytokine storm and the role of ACE2 are currently still not fully understood. |
| T374 |
119-332 |
Sentence |
denotes |
As discussed above, virus binding to the ACE2 is the event that initiates viral replication in susceptible cells, such as alveolar epithelial cells, vascular cells and immune system cells (macrophages, monocytes). |
| T375 |
333-461 |
Sentence |
denotes |
This has been suggested to trigger the primary inflammatory response, which involves apoptosis and pyroptosis (Fu et al., 2020). |
| T376 |
462-712 |
Sentence |
denotes |
The apoptosis pattern indices cell death to avoid viral replication in the absence of overt inflammation, whereas, pyroptosis is a violent form of programmed cell death, followed by an inflammatory storm (Cookson and Brennan, 2001; Liu et al., 2016). |
| T377 |
713-959 |
Sentence |
denotes |
In the standard pyroptosis model, when the pathogen enters the host cell, some specific structures on the pathogen surface (PAMPs–pathogen associated molecular patterns) are identified by pattern recognition receptors (PRRs) on the host membrane. |
| T378 |
960-1405 |
Sentence |
denotes |
One common PRR is NOD-like receptors protein 3 (NLRP3), which forms together with a protein caspase activating protein (ASC or apoptosis-associated speck-like protein containing a caspase recruitment domain) and pro-caspase 1, the inflammasome unit capable of recruiting proinflammatory cytokines and inducing cell lysis with further inflammation signals (Fernandes-Alnemri et al., 2007; Schroder and Tschopp, 2010; Wree et al., 2014; Figure 9). |
