LitCovid-sentences  

PMC:7544943 / 158-1801 JSONTXT 7 Projects

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Id Subject Object Predicate Lexical cue
T7 0-119 Sentence denotes The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel infectious disease that is in rapid growth.
T8 120-195 Sentence denotes Several trials are going on worldwide to find a solution for this pandemic.
T9 196-382 Sentence denotes The viral replication can be blocked by inhibiting the receptor-binding domain (RBD) of SARS-CoV-2 spike protein (SARS-CoV-2 RBD Spro) and the SARS-CoV-2 main protease (SARS-CoV-2 Mpro).
T10 383-501 Sentence denotes The binding of potential small molecules to these proteins can inhibit the replication and transcription of the virus.
T11 502-604 Sentence denotes The spice molecules that are used in our food have antiviral, antifungal and antimicrobial properties.
T12 605-737 Sentence denotes As spice molecules are consumed in the diet, hence its antiviral properties against SARS-CoV-2 will benefit in a significant manner.
T13 738-940 Sentence denotes Therefore, in this work, the molecular docking of 30 selected spice molecules (screened through ADME property) was performed to identify the potential inhibitors for the RBD Spro and Mpro of SARS-CoV-2.
T14 941-1116 Sentence denotes We have found that though all the molecules bind actively with the SARS-CoV-2 RBD Spro and Mpro, but Piperine has the highest binding affinity among the 30 screened molecules.
T15 1117-1227 Sentence denotes Besides, the comparative study between Piperine and currently used drugs show that Piperine is more effective.
T16 1228-1350 Sentence denotes The interaction of Piperine with RBD Spro and Mpro is further validated by the molecular dynamics (MD) simulation studies.
T17 1351-1491 Sentence denotes The free energy landscape and binding free energy results also, support for the stable complex formation of Piperine with RBD Spro and Mpro.
T18 1492-1643 Sentence denotes We anticipate immediate wet-lab experiments and clinical trials in support of this computational study that might help to inhibit the SARS-CoV-2 virus.