| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T273 |
0-141 |
Sentence |
denotes |
Clinical studies have indicated that acute respiratory distress syndrome and multiple organ failure are features of severe cases of COVID-19. |
| T274 |
142-215 |
Sentence |
denotes |
These are thought to be underpinned by an excessive immune response [19]. |
| T275 |
216-358 |
Sentence |
denotes |
In the lung microenvironment, excessive inflammatory cytokine may be caused by immune-pathological changes linked to lymphocytic infiltration. |
| T276 |
359-589 |
Sentence |
denotes |
We demonstrated a significant upregulation of the chemokine receptor CXCR3, which is not only responsible for T cells extravasating from blood vessels and migration [20], but it has been also implicated in pulmonary fibrosis [21]. |
| T277 |
590-709 |
Sentence |
denotes |
It is thus possible that this is associated with an aberrant type I immune response involving the CXCR3/ligand pathway. |
| T278 |
710-952 |
Sentence |
denotes |
In addition, we found intense expression of CD26/DPP4, a protein that plays a key role in T-cell signal transduction processes as a costimulatory molecule, and its expression level is known to correlate with the severity of inflammation [22]. |
| T279 |
953-1098 |
Sentence |
denotes |
Thus, the CXCR3 cytokine axis could be considered a potential therapeutic target in development of targeted host-directed therapies for COVID-19. |
