Id |
Subject |
Object |
Predicate |
Lexical cue |
T4 |
0-8 |
Sentence |
denotes |
Abstract |
T5 |
10-20 |
Sentence |
denotes |
Background |
T6 |
21-317 |
Sentence |
denotes |
Descriptions of the pathological features of coronavirus disease-2019 (COVID-19) caused by the novel zoonotic pathogen severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) emanate from tissue biopsies, case reports, and small postmortem studies restricted to the lung and specific organs. |
T7 |
318-383 |
Sentence |
denotes |
Whole-body autopsy studies of COVID-19 patients have been sparse. |
T8 |
385-392 |
Sentence |
denotes |
Methods |
T9 |
393-681 |
Sentence |
denotes |
To further define the pathology caused by SARS-CoV-2 across all body organs, we performed autopsies on 22 patients with COVID-19 (18 with comorbidities and 4 without comorbidities) who died at the National Institute for Infectious Diseases Lazzaro Spallanzani-IRCCS Hospital, Rome, Italy. |
T10 |
682-785 |
Sentence |
denotes |
Tissues from the lung, heart, liver, kidney, spleen, and bone marrow (but not the brain) were examined. |
T11 |
786-853 |
Sentence |
denotes |
Only lung tissues were subject to transmission electron microscopy. |
T12 |
855-862 |
Sentence |
denotes |
Results |
T13 |
863-901 |
Sentence |
denotes |
COVID-19 caused multisystem pathology. |
T14 |
902-979 |
Sentence |
denotes |
Pulmonary and cardiovascular involvement were dominant pathological features. |
T15 |
980-1133 |
Sentence |
denotes |
Extrapulmonary manifestations included hepatic, kidney, splenic, and bone marrow involvement, and microvascular injury and thrombosis were also detected. |
T16 |
1134-1224 |
Sentence |
denotes |
These findings were similar in patients with or without preexisting medical comorbidities. |
T17 |
1226-1237 |
Sentence |
denotes |
Conclusions |
T18 |
1238-1370 |
Sentence |
denotes |
SARS-CoV-2 infection causes multisystem disease and significant pathology in most organs in patients with and without comorbidities. |