| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T592 |
0-136 |
Sentence |
denotes |
Conversely, direct mitochondrial damage was found to aggravate the production of proinflammatory cytokines and worsen disease prognosis. |
| T593 |
137-325 |
Sentence |
denotes |
Briefly, the pathological changes observed in patients infected with SARS-CoV-2 such as pneumonia, hypoxia and impaired calcium homeostasis can indirectly induce mitochondrial dysfunction. |
| T594 |
326-607 |
Sentence |
denotes |
Moreover, a very recent study conducted by Singh et al. interestingly showed both RNA and RNA transcripts of SARS-CoV-2 can directly target and localize to mitochondria hijacking the host cell's mitochondrial function to viral advantage (Singh, Chaubey, Chen, & Suravajhala, 2020). |
| T595 |
608-754 |
Sentence |
denotes |
Subsequently, SARS-CoV-2 will manipulate the host cell's mitochondrial function to evade removal and facilitate virus replication and progression. |
| T596 |
755-1280 |
Sentence |
denotes |
These effects lead to the release of mitochondrial DNA and ROS in the cytosol (Herst, Rowe, Carson, & Berridge, 2017; Kozlov, Lancaster Jr., Meszaros, & Weidinger, 2017; Mittal, Siddiqui, Tran, Reddy, & Malik, 2014; Starkov, 2008; Twig & Shirihai, 2011; West et al., 2015), which drives the activation and release of central pro-inflammatory cytokines such as NLRP3 inflammasomes, IL-1β and IL-6 (Jo et al., 2016; Naik & Dixit, 2011; Nakahira et al., 2011; West et al., 2015), the hallmark cytokines of the COVID-19 severity. |
| T597 |
1281-1419 |
Sentence |
denotes |
Thus, highlighting a vicious cycle of mitochondrial damage and inflammation that has a critical role in aggravating cardiovascular injury. |
| T598 |
1420-1543 |
Sentence |
denotes |
Accordingly, mitochondria are considered a strategic therapeutic target to improve the outcomes in the context of COVID-19. |
