PMC:7534795 / 36918-37889 JSONTXT 6 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T256 0-94 Sentence denotes • Statin therapy and impact on inflammation and patient prognosis • Retrospective cohort study
T257 95-143 Sentence denotes • Primary endpoint of 28-day all-cause mortality
T258 144-194 Sentence denotes • Secondary endpoint included acute cardiac injury
T259 195-217 Sentence denotes • N = 1219 statin use
T260 218-267 Sentence denotes • N = 12, 762 no statin • In-hospital statin use
T261 268-289 Sentence denotes • Atorvastatin 83.2%,
T262 290-310 Sentence denotes • Rosuvastatin 15.6%
T263 311-521 Sentence denotes • Dose differences between statins were converted to a daily equivalent dose of atorvastatin ranging from 18.9–20.0 mg/day • Reduced all-cause mortality with statin use hazard ratio (HR) 0.63 (95% CI 0.48–0.84)
T264 522-632 Sentence denotes • Patients on ACEi/ARB therapy in addition to statin did not have increased mortality compared to statin alone
T265 633-690 Sentence denotes • Statin therapy not associated with acute cardiac injury
T266 691-971 Sentence denotes • Inflammatory markers CRP, IL-6 were lower in statin treated patients while in hospital • Reduced mortality and improved prognosis associated with in-hospital statin use may be due to the anti-inflammatory and immunomodulatory effects of statins (Zhang, Qin, Cheng, et al., 2020)