| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T164 |
0-166 |
Sentence |
denotes |
Another important finding is that COVID-19 patients with more severe clinical manifestations have higher serum concentrations of IL-6 and lower IFN-γ than mild forms. |
| T165 |
167-240 |
Sentence |
denotes |
This is mainly due to the decrease in CD4+, CD8+ and NK lymphocytes [74]. |
| T166 |
241-370 |
Sentence |
denotes |
Interferons (IFN) are a family of cytokines that play a central role in innate immunity to viruses and other microbial pathogens. |
| T167 |
371-543 |
Sentence |
denotes |
The IFN-receptor binding induces a cascade of signals with activation of genes coding for proteins with antiviral, antiproliferative or immunomodulatory properties [70,75]. |
| T168 |
544-830 |
Sentence |
denotes |
Normally the interaction between the IFN-γ and IL-6/sIL-6R signals contributes to the recruitment and subsequent clearance of neutrophils, thereby controlling infection and resolution of acute inflammation as well as influencing the transition between innate and adaptive immunity [76]. |
| T169 |
831-943 |
Sentence |
denotes |
In patients infected by SARS-CoV-2, a higher IL-6/IFN-γ ratio may be related to an enhanced cytokine storm [74]. |
