| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T830 |
100-311 |
Sentence |
denotes |
Under normal conditions (represented above the dotted line), tight junctions are intact which restricts the leakage of paracellular, typically small hydrophilic, compounds, across the barrier and into the brain. |
| T831 |
312-511 |
Sentence |
denotes |
Additionally, there is a basal expression of efflux transporters, such as P-glycoprotein (P-gp), which effluxes substrates out of the brain, serving to restrict overall accumulation within the brain. |
| T832 |
512-706 |
Sentence |
denotes |
In the setting of HIV and opiate exposure (represented below the dotted line), there is a breakdown of the tight junction proteins and increased leakage of paracellular compounds into the brain. |
| T833 |
707-1028 |
Sentence |
denotes |
Additionally, opiate exposure increases efflux transporter expression, including P-gp and potentially breast cancer resistance protein (Bcrp), thereby restricting overall brain penetration of drugs (like many antiretroviral drugs) which are substrates for these transporters and in response to HIV and/or opioid exposure. |
