LitCovid-sentences  

PMC:7463108 / 1940-5718 JSONTXT 9 Projects

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Id Subject Object Predicate Lexical cue
T14 0-17 Sentence denotes The Opioid Crisis
T15 18-91 Sentence denotes Opioid abuse in the United States (U.S.) has reached catastrophic levels.
T16 92-247 Sentence denotes According to the latest World Drug Report, 53.4 million people worldwide used opioids in 2017, which is 56% higher than in the previous year (UNODC 2019a).
T17 248-406 Sentence denotes North America remains the region with the highest non-medical use of opioids with a staggering 4% of the population aged 15–64 using opioids (UNODC 2019a, c).
T18 407-611 Sentence denotes In 2017, the burden of opioid use in the U.S. had accounted for 42 million healthy years of life lost due to premature death and disability (Institute for Health Metrics and Evaluation 2017; UNODC 2019a).
T19 612-769 Sentence denotes During 2017, there were 70,237 overdose related deaths, out of which 47,600 (67.8%) were caused by opioids, which was a 12% increase from 2016 (Scholl et al.
T20 770-789 Sentence denotes 2018; UNODC 2019c).
T21 790-928 Sentence denotes The Centers of Disease Control and Prevention (CDC) reports that on average 130 Americans die from an opioid overdose each day (CDC 2017).
T22 929-991 Sentence denotes Due to the constant rise in deaths involving opioids, the U.S.
T23 992-1078 Sentence denotes Government declared the opioid crisis/epidemic a public health emergency in 2017 (U.S.
T24 1079-1125 Sentence denotes Department of Health and Human Services 2017).
T25 1126-1331 Sentence denotes Injection drug use increases the likelihood of contracting human immunodeficiency virus (HIV) and drug abuse and HIV have long been described as interrelated epidemics (Swan 1997; Leshner 1998; Nath et al.
T26 1332-1344 Sentence denotes 1999, 2002).
T27 1345-1484 Sentence denotes Despite this understanding, opioid use disorder (OUD) and HIV remain a huge public health concern (Strathdee and Beyrer 2015; Peters et al.
T28 1485-1491 Sentence denotes 2016).
T29 1492-1669 Sentence denotes In fact, the opioid crisis is seen as a major roadblock in several aspects of public health, including thwarting the goal of eliminating HIV within the next decade (Fauci et al.
T30 1670-1699 Sentence denotes 2019; Lerner and Fauci 2019).
T31 1700-1797 Sentence denotes OUD is also likely to exacerbate many negative aspects of the COVID-19 pandemic (Alexander et al.
T32 1798-1854 Sentence denotes 2020; Becker and Fiellin 2020; NIDA 2020; Wakeman et al.
T33 1855-1861 Sentence denotes 2020).
T34 1862-2224 Sentence denotes Not only are individuals with OUD more vulnerable to SARS-CoV-2 and liable to spread the infection, social-distancing practices create isolation, despair, and economic hardships, heightening opioid abuse (with inherent respiratory depression depending on the amount of tolerance developed) and the probability of overdose (Becker and Fiellin 2020; Wakeman et al.
T35 2225-2231 Sentence denotes 2020).
T36 2232-2481 Sentence denotes By virtue of its greater safety profile and decreased likelihood for abuse (Bell and Strang 2020), the use of buprenorphine via telemedicine has become advantageous for managing OUD during the COVID-19 pandemic (Leppla and Gross 2020; Samuels et al.
T37 2482-2542 Sentence denotes 2020) but presents new challenges (Khatri and Perrone 2020).
T38 2543-2653 Sentence denotes The current opioid crisis did not happen quickly; in fact, it has been described as occurring in three phases.
T39 2654-2749 Sentence denotes The first phase began in the late 1990s with an increase in the number of prescription opioids.
T40 2750-2874 Sentence denotes This led to overdose deaths that were attributable to natural and semi-synthetic opioids, such as methadone (Kolodyny et al.
T41 2875-2891 Sentence denotes 2015; CDC 2017).
T42 2892-2995 Sentence denotes The second phase began in 2010 in which heroin took the lead as the principal cause of overdose deaths.
T43 2996-3165 Sentence denotes The most recent, third wave, began in 2013 in which highly potent synthetic opioids, such as fentanyl and its analogs became the main cause of mortality (Kolodyny et al.
T44 3166-3182 Sentence denotes 2015; CDC 2017).
T45 3183-3306 Sentence denotes The entry of fentanyl and its analogs into the clandestine market has changed the dynamics of the opioid market in the U.S.
T46 3307-3530 Sentence denotes The synthetic opioids, such as fentanyl, are several orders of magnitude more potent than morphine, easily smuggled, and frequently and inconsistently mixed with lower quality drugs increasing the probability of overdosing.
T47 3531-3607 Sentence denotes According to the National Forensic Laboratory Information System of the U.S.
T48 3608-3778 Sentence denotes Drug Enforcement Administration (DEA), fentanyl accounted for one-third of the illicit opioids seized in 2017 (UNODC 2019c) and has become a global problem (UNODC 2019b).