PMC:7461420 / 69571-70195 7 Projects
Annnotations
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T605 | 197-282 | Sentence | denotes | The compound with an R‐configuration occupied the S3‐S1' subsites of SARS‐CoV‐1 Mpro. |
| T606 | 283-624 | Sentence | denotes | Indeed, only (R)‐123 was able to inhibit the Mpro enzyme with an IC50 value of 1.5 µM, while the (S)‐enantiomer was inactive. (R)‐123 inhibited SARS‐CoV‐1 Mpro in a competitive manner (K i, 1.6 µM) with a noncovalent mode of inhibition. (R)‐123 also showed antiviral activity (12.9 µM) in mock infected and SARS‐CoV‐1 infected Vero E6 cells. |