| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T303 |
0-175 |
Sentence |
denotes |
Human cathepsin L is a cysteine endopeptidase and plays a key role for infection efficiency by activation of the S protein into a fusogenic state to escape the late endosomes. |
| T304 |
176-327 |
Sentence |
denotes |
Targeting this protease with small molecules could interfere with virus‐cell entry and therefore be a possible intervention strategy for CoV infection. |
| T305 |
328-542 |
Sentence |
denotes |
114 Bates et al. identified MDL28170 (20; Figure 9) as an antiviral compound that specifically inhibited cathepsin‐L‐mediated substrate cleavage, with an IC50 value of 2.5 nM and EC50 value in the range of 100 nM. |
| T306 |
543-643 |
Sentence |
denotes |
However, despite its potent inhibitory activity, no cytotoxicity data for 20 is currently available. |
| T307 |
644-647 |
Sentence |
denotes |
115 |
