PMC:7461420 / 19353-20038 JSONTXT 9 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T193 0-118 Sentence denotes The genetic code of SARS‐CoV‐2 shares noticeable similarities with SARS‐CoV‐1, which caused the SARS epidemic in 2002.
T194 119-199 Sentence denotes 26 , 54 More importantly, both viruses have identical mechanisms of infection.
T195 200-382 Sentence denotes SARS‐CoV‐1 uses the host's ACE2 as a portal to infect cells, which has high expression in the vascular endothelium 55 and the lung, particularly in type 2 alveolar epithelial cells.
T196 383-450 Sentence denotes 56 SARS‐CoV‐2 shares 76% of its spike (S) protein with SARS‐CoV‐1.
T197 451-685 Sentence denotes Despite a few amino acid differences in its RBD compared to the SARS‐CoV‐1 S protein, the SARS‐CoV‐2 S protein binds to ACE2 with even greater affinity 27 offering an explanation for its greater virulence and preference for the lung.