PMC:7449695 / 26038-27876 JSONTXT 5 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T180 0-36 Sentence denotes Reporting delays and under-reporting
T181 37-320 Sentence denotes A pre-hoc statistical analysis was conducted in order to estimate a distribution of the reporting delays from the line-lists of cases, using the code base provided by London School of Hygiene & Tropical Medicine Mathematical Modelling of Infectious Diseases nCoV working group, 2020.
T182 321-391 Sentence denotes The estimated reporting delay is assumed to remain constant over time.
T183 392-569 Sentence denotes These reporting delays are used to: (i) infer the time of symptom onset for those without this information, and; (ii) infer how many cases in recent days are yet to be recorded.
T184 570-687 Sentence denotes Adjusting for reporting delays is critical for inferring when a drop in observed cases reflects a true drop in cases.
T185 688-786 Sentence denotes Trends identified using this approach are robust to under-reporting, assuming that it is constant.
T186 787-853 Sentence denotes However, absolute values of Rš‘’š‘“š‘“ may be biased by reporting rates.
T187 854-930 Sentence denotes Pronounced changes in reporting rates may also impact the trends identified.
T188 931-1071 Sentence denotes The delay from symptom onset to reporting is likely to decrease over the course of the epidemic, due to improved surveillance and reporting.
T189 1072-1300 Sentence denotes We used a delay distribution estimated from observed reporting delays from the analysis period, which is therefore likely to underestimate reporting delays early in the epidemic, and overestimate them as the epidemic progressed.
T190 1301-1593 Sentence denotes Underestimating the delay would result in an overestimate of Rš‘’š‘“š‘“, as the inferred onset dates (for those that were unknown) and adjustment for right-truncation, would result in more concentrated inferred daily cases (i.e., the inferred cases would be more clustered in time than in reality).
T191 1594-1651 Sentence denotes The converse would be true when overestimating the delay.
T192 1652-1838 Sentence denotes The impact of this misspecified distribution will be greatest on the most recent estimates of Rš‘’š‘“š‘“, where inference for both right-truncation and missing symptom onset dates is required.