LitCovid-sentences  

PMC:7441788 / 5971-7424 JSONTXT 16 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T47 0-2 Sentence denotes 3.
T48 4-60 Sentence denotes Antiviral activity of CQ/HCQ against SARS-CoV-2 in vitro
T49 61-169 Sentence denotes In VeroE6 cells, the EC50, CC50 and SI of CQ against SARS-CoV-2 were 1.13 μM, >100 and >88.50, respectively.
T50 170-254 Sentence denotes CQ functioned at the entry, and post-entry stages of SARS-CoV-2 infected cells [16].
T51 255-485 Sentence denotes In the same cell line, at different multiplicities of infection (MOIs, 0.01, 0.02, 0.2, and 0.8) of SARS-CoV-2, the EC50 for CQ (2.71, 3.81, 7.14, and 7.36 μM) was slightly lower than that of HCQ (4.51, 4.06, 17.31, and 12.96 μM).
T52 486-618 Sentence denotes Consequently, the SI of CQ (100.81, 71.71, 38.26, and 37.12) was slightly higher than that of HCQ (55.32, 61.45, 14.41, 19.25) [17].
T53 619-724 Sentence denotes These results indicate that the anti-SARS-CoV-2 activity of CQ seems to be more potent than HCQ in vitro.
T54 725-1152 Sentence denotes However, another in vitro cell experiment showed that after SARS-CoV-2 infection of VeroE6 cells, the EC50 values for CQ were 23.90 μM and 5.47 μM, and EC50 values for HCQ were 6.14 μM and 0.72 μM, at 24 and 48 h, respectively; When administered prior to SARS-CoV-2 infection of VeroE6 cells, EC50 values for CQ were >100 μM and 18.01 μM, and the EC50 values for HCQ were 6.14 μM and 0.72 μM, at 24 and 48 h, respectively [18].
T55 1153-1242 Sentence denotes These results showed that the anti-SARS-CoV-2 activity of CQ was worse than HCQ in vitro.
T56 1243-1365 Sentence denotes The conflicting results of these two studies may be related to different cell culture methods and experimental conditions.
T57 1366-1453 Sentence denotes In short, these in vitro studies show that CQ/HCQ have strong anti-SARS-CoV-2 activity.