| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T220 |
222-529 |
Sentence |
denotes |
The top-eight scoring ligands for the SARS-CoV-2 RdRp (as highlighted in Table 1) suggest that these set of natural polyphenols can strongly bind to the catalytic site of the SARS-CoV-2 RdRp and are expected to inhibit the RdRp activity, and thus blocking the replication and preventing viral transcription. |
| T221 |
530-682 |
Sentence |
denotes |
Many reports suggest polyphenols have low systemic toxicity, and they are highly beneficial for human health (Bhardwaj et al., 2020; Cory et al., 2018). |
| T222 |
683-911 |
Sentence |
denotes |
TF1 and its gallate derivatives, collectively known as black tea polyphenols, previously have shown to exert antiviral activity against many viruses such as hepatitis virus and influenza A and B viruses (Chowdhury et al., 2018). |
| T223 |
912-1084 |
Sentence |
denotes |
Hesperidin is also known to possess antiviral activity by altering the immune system mainly via regulating interferons in the influenza A virus (Randall & Goodbourn, 2008). |
| T224 |
1085-1235 |
Sentence |
denotes |
EGCG, a major green tea polyphenol, has several pharmacological properties, including antiviral activity (Carneiro et al., 2016; Moon & Morris, 2007). |
| T225 |
1236-1351 |
Sentence |
denotes |
Similarly, myricetin has also been found to act as an inhibitor of the SARS coronavirus helicase (Yu et al., 2012). |
| T226 |
1352-1474 |
Sentence |
denotes |
Quercetagetin also showed strong hepatitis C virus replication inhibitory activity in vitro (Ahmed-Belkacem et al., 2014). |
| T227 |
1475-1667 |
Sentence |
denotes |
Thus, the set dietary polyphenols identified in the present study could be used as repurposed drugs for the treatment of the SARS-CoV-2 infection with further in-vitro and in-vivo validations. |
