| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T3 |
0-91 |
Sentence |
denotes |
Age-associated changes in immune cells have been linked to an increased risk for infection. |
| T4 |
92-219 |
Sentence |
denotes |
However, a global and detailed characterization of the changes that human circulating immune cells undergo with age is lacking. |
| T5 |
220-393 |
Sentence |
denotes |
Here, we combined scRNA-seq, mass cytometry and scATAC-seq to compare immune cell types in peripheral blood collected from young and old subjects and patients with COVID-19. |
| T6 |
394-719 |
Sentence |
denotes |
We found that the immune cell landscape was reprogrammed with age and was characterized by T cell polarization from naive and memory cells to effector, cytotoxic, exhausted and regulatory cells, along with increased late natural killer cells, age-associated B cells, inflammatory monocytes and age-associated dendritic cells. |
| T7 |
720-870 |
Sentence |
denotes |
In addition, the expression of genes, which were implicated in coronavirus susceptibility, was upregulated in a cell subtype-specific manner with age. |
| T8 |
871-1003 |
Sentence |
denotes |
Notably, COVID-19 promoted age-induced immune cell polarization and gene expression related to inflammation and cellular senescence. |
| T9 |
1004-1217 |
Sentence |
denotes |
Therefore, these findings suggest that a dysregulated immune system and increased gene expression associated with SARS-CoV-2 susceptibility may at least partially account for COVID-19 vulnerability in the elderly. |
