PMC:7417114 / 85891-86425 JSONTXT 10 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T633 0-141 Sentence denotes Afatinib has also been tested in combination with nintedanib in a Phase I dose-escalation study in patients with advanced solid tumors (182).
T634 142-305 Sentence denotes It was determined that afatinib at 10 mg/day combined with nintedanib at 200 mg twice a day had a manageable safety profile, however the doses were subtherapeutic.
T635 306-534 Sentence denotes The antifibrotic and anti-inflammatory potential of afatinib and nintedanib, coupled with key virus-associated protein targets for each (Table 2, Fig. 3), warrant investigation of this drug combination for treatment of COVID-19.