| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T340 |
0-19 |
Sentence |
denotes |
Bosutinib (Bosulif) |
| T341 |
20-110 |
Sentence |
denotes |
(Pfiizer) Food increases exposure; following 15 daily doses of bosutinib 500 mg with food: |
| T342 |
111-148 |
Sentence |
denotes |
Cmax = 200 ng/mL; AUC = 3650 ng∙h/mL; |
| T343 |
149-281 |
Sentence |
denotes |
compared to initial administration, plasma drug exposure did not increase significantly; following 15 daily doses 400 mg once daily: |
| T344 |
282-300 |
Sentence |
denotes |
AUC =2235 ng*h/mL; |
| T345 |
301-310 |
Sentence |
denotes |
Tmax=4 h; |
| T346 |
311-335 |
Sentence |
denotes |
Has acceptable exposure; |
| T347 |
336-354 |
Sentence |
denotes |
Vd= 6080 ± 1230 L; |
| T348 |
355-669 |
Sentence |
denotes |
(substrate of ABCB1) Metabolized mainly by CYP3A4, which can increase AUC and Cmax 500 mg orally once daily (chronic myeloid leukmia (chronic and accelerated phases and blast crisis with resistance/intolerance to prior therapy)); 400 mg orally once daily (newly diagnosed chronic myeloid leukemia (chronic phase)); |
| T349 |
670-911 |
Sentence |
denotes |
94% binding to human plasma proteins in vitro; 96% bound to human plasma proteins in healthy subjects ex vivo Pleural effusion is the main lung toxicity associated with bosutinib; 8% of patients in one study developed pleural effusions (207) |
