Id |
Subject |
Object |
Predicate |
Lexical cue |
T754 |
0-112 |
Sentence |
denotes |
Recently, another FDA-approved drug, ivermectin, was reported to inhibit the in vitro replication of SARS-CoV-2. |
T755 |
113-280 |
Sentence |
denotes |
The findings from this study indicate that a single treatment of this drug was able to induce an ∼5,000-fold reduction in the viral RNA at 48 h in cell culture. (308). |
T756 |
281-396 |
Sentence |
denotes |
One of the main disadvantages that limit the clinical utility of ivermectin is its potential to cause cytotoxicity. |
T757 |
397-589 |
Sentence |
denotes |
However, altering the vehicles used in the formulations, the pharmacokinetic properties can be modified, thereby having significant control over the systemic concentration of ivermectin (338). |
T758 |
590-924 |
Sentence |
denotes |
Based on the pharmacokinetic simulation, it was also found that ivermectin may have limited therapeutic utility in managing COVID-19, since the inhibitory concentration that has to be achieved for effective anti-SARS-CoV-2 activity is far higher than the maximum plasma concentration achieved by administering the approved dose (340). |
T759 |
925-1066 |
Sentence |
denotes |
However, ivermectin, being a host-directed agent, exhibits antiviral activity by targeting a critical cellular process of the mammalian cell. |
T760 |
1067-1177 |
Sentence |
denotes |
Therefore, the administration of ivermectin, even at lower doses, will reduce the viral load at a minor level. |
T761 |
1178-1322 |
Sentence |
denotes |
This slight decrease will provide a great advantage to the immune system for mounting a large-scale antiviral response against SARS-CoV-2 (341). |
T762 |
1323-1540 |
Sentence |
denotes |
Further, a combination of ivermectin and hydroxychloroquine might have a synergistic effect, since ivermectin reduces viral replication, while hydroxychloroquine inhibits the entry of the virus in the host cell (339). |
T763 |
1541-1701 |
Sentence |
denotes |
Further, in vivo studies and randomized clinical control trials are required to understand the mechanism as well as the clinical utility of this promising drug. |