LitCovid-sentences  

PMC:7405836 / 110553-112254 JSONTXT 9 Projects

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Id Subject Object Predicate Lexical cue
T754 0-112 Sentence denotes Recently, another FDA-approved drug, ivermectin, was reported to inhibit the in vitro replication of SARS-CoV-2.
T755 113-280 Sentence denotes The findings from this study indicate that a single treatment of this drug was able to induce an ∼5,000-fold reduction in the viral RNA at 48 h in cell culture. (308).
T756 281-396 Sentence denotes One of the main disadvantages that limit the clinical utility of ivermectin is its potential to cause cytotoxicity.
T757 397-589 Sentence denotes However, altering the vehicles used in the formulations, the pharmacokinetic properties can be modified, thereby having significant control over the systemic concentration of ivermectin (338).
T758 590-924 Sentence denotes Based on the pharmacokinetic simulation, it was also found that ivermectin may have limited therapeutic utility in managing COVID-19, since the inhibitory concentration that has to be achieved for effective anti-SARS-CoV-2 activity is far higher than the maximum plasma concentration achieved by administering the approved dose (340).
T759 925-1066 Sentence denotes However, ivermectin, being a host-directed agent, exhibits antiviral activity by targeting a critical cellular process of the mammalian cell.
T760 1067-1177 Sentence denotes Therefore, the administration of ivermectin, even at lower doses, will reduce the viral load at a minor level.
T761 1178-1322 Sentence denotes This slight decrease will provide a great advantage to the immune system for mounting a large-scale antiviral response against SARS-CoV-2 (341).
T762 1323-1540 Sentence denotes Further, a combination of ivermectin and hydroxychloroquine might have a synergistic effect, since ivermectin reduces viral replication, while hydroxychloroquine inhibits the entry of the virus in the host cell (339).
T763 1541-1701 Sentence denotes Further, in vivo studies and randomized clinical control trials are required to understand the mechanism as well as the clinical utility of this promising drug.