LitCovid-sentences  

PMC:7402624 / 39188-41269 JSONTXT 9 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T226 0-192 Sentence denotes We next asked whether these T and B cell dynamics related to clinical measures of COVID-19 disease, by correlating changes in immune features from D0 to D7 with clinical information (Fig. 5G).
T227 193-239 Sentence denotes These analyses revealed distinct correlations.
T228 240-482 Sentence denotes Decreases in all populations of responding CD4 and CD8 T cells (HLA-DR+CD38+, KI67+, or activated cTfh) between D0 and D7 were positively correlated with PMN and WBC counts, suggesting a relationship between T cell activation and lymphopenia.
T229 483-586 Sentence denotes Furthermore, decreases in CD4 and CD8 HLA-DR+CD38+ T cells positively correlated with APACHE III score.
T230 587-692 Sentence denotes However, stable HLA-DR+CD38+ CD4 T cell responses correlated with coagulation complications and ferritin.
T231 693-807 Sentence denotes Whereas decreasing activated cTfh over time was related to co-infection, the opposite pattern was observed for PB.
T232 808-1089 Sentence denotes Increases in proliferating KI67+ CD4 and CD8 T cells over time were positively correlated to increasing anti-SARS-CoV2 antibody from day 0 to day 7, suggesting that some individuals might have been hospitalized during the expansion phase of the antiviral immune response (Fig. 5G).
T233 1090-1193 Sentence denotes Finally, neither Remdesivir nor HCQ treatment correlated with any of these immune features in Fig. 5G).
T234 1194-1409 Sentence denotes Examining categorical rather than continuous clinical data, 80% of patients with decreasing PB over time had hyperlipidemia, whereas only 20% of patients with increasing PB over time had this comorbidity (fig. S6D).
T235 1410-1674 Sentence denotes All patients who had decreasing CD38+HLA-DR+ CD8 T cells from day 0 to day 7 were treated with early vasoactive medication or inhaled nitric oxide whereas these treatments were less common for patients with stable or increasing CD38+HLA-DR+ CD8 T cells (fig. S6E).
T236 1675-1837 Sentence denotes In contrast, vasoactive medication, inhaled nitric oxide, and early steroid treatment were equally common in patients with increasing or decreasing PB (fig. S6D).
T237 1838-1945 Sentence denotes Similar patterns were apparent for other T cell populations and these categorical clinical data (fig. S6F).
T238 1946-2081 Sentence denotes Thus, the trajectory of change in the T and B cell response in COVID-19 patients was strongly connected to clinical metrics of disease.