LitCovid-sentences  

PMC:7396557 / 50893-53904 JSONTXT 11 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T382 0-45 Sentence denotes Progress of Pharmacological Research on SFJDC
T383 46-211 Sentence denotes Modern pharmacological studies have found that SFJDC has antiviral, antibacterial, and anti-inflammatory properties and protects against lung injury (see Table 3 ).
T384 212-325 Sentence denotes Yanyan Bao et al. evaluated the broad-spectrum antiviral activity of SFJDC by cytopathic effect (CPE) inhibition.
T385 326-472 Sentence denotes A total of eight viruses, including H1N1, herpes simplex (HSV), respiratory syncytial virus, adenovirus (ADV) and Coxsackie virus, were evaluated.
T386 473-607 Sentence denotes SFJDC had significant in vitro broad-spectrum antiviral activity and the best inhibitory effect was against parainfluenza virus (PIV).
T387 608-700 Sentence denotes Similar results were obtained from in vivo experiments (Qiu et al., 2014; Bao et al., 2019).
T388 701-824 Sentence denotes Ying Liu et al. used H1N1 FM1 and PR8 strains to induce nasal drip infection in an immunocompromised mouse pneumonia model.
T389 825-914 Sentence denotes Therapeutic and preventive effects of SFJDC were observed against H1N1 infection in vivo.
T390 915-1181 Sentence denotes The results showed that SFJDC influenced the immune function of the mice, improved pneumonia symptoms caused by influenza virus, reduced the lung index of mice infected with H1N1, significantly reduced mortality, and had good therapeutic efficacy (Liu et al., 2010).
T391 1182-1290 Sentence denotes Research by Weiwei Lv et al. found that SFJDC had inhibitory activity against multiple viruses and bacteria.
T392 1291-1380 Sentence denotes Its antiviral activity was inferior to that of Ribavirin, but its cytotoxicity was lower.
T393 1381-1502 Sentence denotes Both antiviral activity and antibacterial action were superior to those of Qingkailing granules (QKLG) (Lv et al., 2013).
T394 1503-1631 Sentence denotes Li Ma et al. used a mouse pneumonia model induced by Streptococcus pneumoniae to study the anti-inflammatory mechanism of SFJDC.
T395 1632-1883 Sentence denotes They discovered that it reduced white blood cell (WBC) count, reduced serum levels of the transcription factor nuclear factor kappa B (NF-κB), MCP-1, inflammatory mediator BK and COX-2, thus, having a therapeutic effect in the model (Ma et al., 2018).
T396 1884-2107 Sentence denotes Further studies found that SFJDC had a significant immune regulatory function, reducing levels of B lymphocytes, CD8+ cells, interleukin-1α (IL-1α), IL-1β, IL-2, IgM, and IgG to improve lung function in mice with pneumonia.
T397 2108-2279 Sentence denotes SFJDC increased the CD4+/CD8+ ratio and number of natural killer (NK) cells, thus, having a therapeutic effect in the pneumonia model (Ma et al., 2019a; Ma et al., 2019b).
T398 2280-2386 Sentence denotes Zhengang Tao et al. observed a protective function of SFJDC against endotoxin LPS-induced rat lung injury.
T399 2387-2504 Sentence denotes Their results showed that SFJDC inhibited the LPS-induced inflammatory response, and reduced LPS-induced lung injury.
T400 2505-2683 Sentence denotes Its mechanism of action might be inhibition of the MAPK (mitogen-activated protein kinase)/NF-κB signaling pathway and downregulation of NF-κB mRNA expression (Tao et al., 2014).
T401 2684-2851 Sentence denotes Yanmei Li et al. used a Pseudomonas aeruginosa (PAK)-induced KM mouse acute lung injury model to explore the mode of action of SFJDC in treatment of acute lung injury.
T402 2852-3011 Sentence denotes They found that SFJDC significantly alleviated lung injury in the model and its mode of action might be related to the ERK signaling pathway (Li et al., 2017).