LitCovid-sentences  

PMC:7386875 / 36017-38583 JSONTXT 11 Projects

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Id Subject Object Predicate Lexical cue
T120 0-211 Sentence denotes One of the striking observations in severe COVID-19 is the correlation between inflammatory markers, such as CRP, ferritin and IL-6 and a raised D-dimer, the latter reporting on an activated coagulation pathway.
T121 212-669 Sentence denotes Although a full discussion regarding the pathological hyperinflammatory response observed in severe COVID-19 is beyond the scope of this review, there is mounting evidence that monocytes/macrophages play a central role in this process.104 This is perhaps best highlighted by the observation that patients with severe COVID-19 in ICU exhibit a significant expansion of CD14+CD16+ monocytes producing IL-6 compared with nonhospitalized patients with COVID-19.
T122 670-820 Sentence denotes As discussed above, this is particularly relevant in the context of thrombosis given the bidirectional relationship between monocytes and coagulation.
T123 821-936 Sentence denotes First, activated platelets form heterotypic aggregates with monocytes in the setting of infection and inflammation.
T124 937-2566 Sentence denotes Platelet-monocyte aggregates may play a role in mechanical occlusion of the microvasculature in addition to altering platelet and monocyte functional responses.110,111 In this regard, platelets induce monocyte NF-κB (nuclear factor κ light-chain-enhancer of activated B cells) signaling and thereby modulate monocyte effector functions and induce the synthesis of the proinflammatory cytokines IL-8 and MCP-1.112 Moreover, platelet P-selectin induces monocyte TF expression and upregulates the expression of monocyte Mac-1 (αMβ2, CD11b/CD18).113,114 The platelet-derived chemokines, PF-4 and CXCL-12, enhance monocyte survival and facilitate differentiation into macrophages,115,116 while activated platelets also enhance the phagocytic activity of macrophages.117 A consistent feature of COVID-19 is the finding that patients with existing cardiovascular risk factors are at an increased risk of severe COVID-19 and have higher fatality rates from the disease.34,35 It is noteworthy that oxidized phospholipids, which are strongly associated with atherosclerosis, have been detected in the lungs of patients with SARS-CoV.118,119 OxPLs (oxidised phospholipids) are generated by reactive oxygen species and play important roles in regulating inflammation given their demonstrated roles in promoting monocyte TF production, monocyte activation, and endothelial cell activation.104 The oxidized phospholipid, oxPAPC, has been demonstrated to play a central role in the pathogenesis of a murine model of SARS-induced acute lung injury in a process linked to monocyte/macrophage activation via the TLR-4-TRIF-TRAF-6-NF-κB pathway.119