| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T116 |
0-70 |
Sentence |
denotes |
The contribution of platelets to vascular integrity, growth and repair |
| T117 |
71-162 |
Sentence |
denotes |
The interactions between platelets and the vascular endothelium are a tightly orchestrated. |
| T118 |
163-313 |
Sentence |
denotes |
In response to inflammatory stimuli, P-selectin rapidly translocates from membranes of storage granules (Weibel-Palade bodies) to the plasma membrane. |
| T119 |
314-393 |
Sentence |
denotes |
GPIbα present on platelets recognizes and binds to endothelial cell P-selectin. |
| T120 |
394-570 |
Sentence |
denotes |
Firm adhesion of platelets to intact endothelial cells depends on platelet integrin αIIbβ3 bridging to endothelial receptors such as αVβ3 and intercellular adhesion molecule-1. |
| T121 |
571-662 |
Sentence |
denotes |
Ligands for bridging include fibrinogen, fibronectin, and von Willebrand factor (VWF) [33]. |
| T122 |
663-712 |
Sentence |
denotes |
Inflammatory cytokines augment platelet adhesion. |
| T123 |
713-860 |
Sentence |
denotes |
Platelets are essential for maintaining vascular integrity [34] and endothelial barrier function, particularly in the setting of inflammation [35]. |
| T124 |
861-994 |
Sentence |
denotes |
In addition to physical interactions, platelets promote vascular integrity through synthesis and release of bioactive mediators [36]. |
