LitCovid-sentences  

PMC:7373848 / 13531-17109 JSONTXT 12 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T87 0-43 Sentence denotes How do endothelial cells facilitate repair?
T88 44-217 Sentence denotes Angiopoietin-1 tyrosine protein kinase receptor related Tie-2 signaling in endothelial cells plays a pivotal role in wound healing, vascular integrity and angiogenesis [25].
T89 218-413 Sentence denotes Individually, angiopoietin (ANG)-1 is essential for blood vessel growth and maturation, and ANG-2 acts in combination with vascular endothelial cell growth factor (VEGF) to initiate angiogenesis.
T90 414-500 Sentence denotes In conditions like cancer, there is an upregulation and over-expression of ANG-2 [25].
T91 501-606 Sentence denotes ANG-1 is chemotactic for endothelial cells, but neither ANG-1 nor ANG-2 exert proliferative effects [26].
T92 607-645 Sentence denotes ANG-2 is a natural inhibitor of ANG-1.
T93 646-767 Sentence denotes Endothelial cells express ANG-2 mRNA and protein, supporting the potential for autocrine activation of angiopoietin/Tie2.
T94 768-846 Sentence denotes ANG-1 and Tie-2 are highly expressed in both arteries and veins [27] (Fig. 5).
T95 847-965 Sentence denotes Fig. 5 Schematic representation of the Ang2 effect on the vascular bed in normal conditions, inflammation, and cancer.
T96 966-1076 Sentence denotes Under normal physiological conditions, Ang2 levels are low, but are upregulated during inflammation or cancer.
T97 1077-1355 Sentence denotes Ang2 acts on endothelial cells, increasing endothelial permeability and also on the pericytes, causing pericyte detachment from the basement membrane, further inducing vascular leakiness, immune or/and cancer cell trans-endothelial migration, and deterioration of the condition.
T98 1356-1418 Sentence denotes Ang2 has been proposed as a marker for inflammatory conditions
T99 1419-1434 Sentence denotes (From Akwii RG.
T100 1435-1453 Sentence denotes Cells 2019; 8:471.
T101 1454-1470 Sentence denotes With permission)
T102 1471-1567 Sentence denotes The tyrosine kinase family of cell surface proteins plays an important role in vascular biology.
T103 1568-1778 Sentence denotes In response to a variety of conditions/environment-specific signals, tyrosine kinases engage in proliferation, migration, differentiation and morphologic organization that aligns with surroundings tissues [28].
T104 1779-1965 Sentence denotes Tyrosine kinases are commonly distinguished from one-another according to structural and sequence characteristics e.g. vascular endothelial growth factors (VEGF-R1, VEGF-R2 and VEGF-R3).
T105 1966-2034 Sentence denotes Each plays an essential role in maintaining vascular integrity [29].
T106 2035-2259 Sentence denotes The Tie [tyrosine kinase with immunoglobulin and epidermal growth factor (EGF) homology domains] receptor family represent a second sub-family of endothelial cell receptor tyrosine kinases identified as Tie-1 and Tie-2 [30].
T107 2260-2448 Sentence denotes Tie-1 and Tie-2 are vital to maintain growth and integrity of the vasculature, including endothelial cell-smooth muscle cell communication in vascular morphogenesis (see discussion above).
T108 2449-2527 Sentence denotes Infectious diseases affecting the lungs cause varying degrees of inflammation.
T109 2528-2637 Sentence denotes Dysregulated inflammation is particularly deleterious and often associated with endothelial cell dysfunction.
T110 2638-2838 Sentence denotes Trent et al. [31] reported dysregulated pulmonary inflammation and Tie-2-related endothelial dysfunction contributing to lung damage and mortality in a murine model of Orienta Tsutsugamushi infection.
T111 2839-3089 Sentence denotes Tissue findings included a high level of Ang-2 proteins in pulmonary endothelial cells, a progressive loss of endothelial cell quiescent and junction proteins, and a substantial decrease in Tie-2 receptor at the transcriptional and functional levels.
T112 3090-3174 Sentence denotes In-vitro infection of primary human endothelial cells demonstrated similar findings.
T113 3175-3299 Sentence denotes Tie-1 is upregulated by oscillating shear stress and differentially expressed in a dynamic pattern with disturbed flow [32].
T114 3300-3462 Sentence denotes Tie-1 deletion in mice causes abnormal extracellular matrix deposition and remodeling characterized by increased glycosaminoglycan and decreased collagen content.
T115 3463-3578 Sentence denotes The findings suggest that abnormal blood flow is a stimulus for endothelial cell Tie1-mediated paracrine signaling.