PMC:7361216 / 7064-8033 JSONTXT 19 Projects

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Id Subject Object Predicate Lexical cue
T44 0-121 Sentence denotes In the so‐called receptor‐binding domain of the spike protein there are 22 glycan‐binding sites (Shahajan, Supekar et al.
T45 122-128 Sentence denotes 2020).
T46 129-252 Sentence denotes High mannose, hybrid and complex‐type glycans across the N‐glycosylation sites have been identified with mass spectrometry.
T47 253-461 Sentence denotes One could imagine building a therapeutic which might contain the carbohydrates, or a suitable mimic, of the spike protein coupled to a carrier molecule, much in a similar fashion to how PPSGG was constructed.
T48 462-613 Sentence denotes Such a “decoy” carbohydrate could block the binding and subsequent internalization of COViD‐19 to its receptor, angiotensin converting enzyme‐2 (ACE2).
T49 614-715 Sentence denotes In addition, spike carbohydrate clusters coupled to a carrier might proof to be an effective vaccine.
T50 716-848 Sentence denotes Both the pneumococcal vaccine and the meningococcal vaccines target polysaccharides in pneumococcus and meningococcus, respectively.
T51 849-969 Sentence denotes They couple the appropriate polysaccharide to a suitable carrier to achieve potent carbohydrate‐specific immunogenicity.