LitCovid-sentences  

PMC:7358770 / 6564-10644 JSONTXT 14 Projects

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Id Subject Object Predicate Lexical cue
T43 0-44 Sentence denotes 2.1 Source and structure of polysaccharides
T44 45-242 Sentence denotes The main sources of polysaccharides are endogenous glycosaminoglycans (GAGs), Marine polysaccharides and terrestrial plant polysaccharides, especially polysaccharides from Chinese herbal medicines.
T45 243-510 Sentence denotes GAGs are naturally-derived linear polysaccharides that are expressed in the intracellular compartments, cell surface, and extracellular environments, and they interact with various molecules to regulate many cellular processes associated with health and disease [22].
T46 511-713 Sentence denotes GAGs are comprised distinct O-linked disaccharide units, which are typically composed of a combination of iduronic acid, glucuronic acid, glucosamine, galactose or galactosamine monosaccharides [23,24].
T47 714-853 Sentence denotes The widely studied GAGs mainly include chondroitin sulfate (CS), heparan sulfate (HS) and heparin (HP) in animal tissues (Fig. 3 ) [22,25].
T48 854-990 Sentence denotes GAG chains are in most cases sulfated, except hyaluronan (HA) (Fig. 3), which are biodegradable and non-immunogenic in the body [26,27].
T49 991-1051 Sentence denotes The chemical structures of typical GAGs are shown in Fig. 3.
T50 1052-1171 Sentence denotes Fig. 3 The structures of several polysaccharides (GAGs, marine polysaccharides, and terrestrial plant polysaccharides).
T51 1172-1225 Sentence denotes Marine organisms are rich sources of polysaccharides.
T52 1226-1442 Sentence denotes Chitosan is a linear, positive-charged, alkaline polysaccharide repeating by glucosamine and N-acetylglucosamine (Fig. 3) [28,29], derived from the shells of shrimps and crustacean or the cell walls of fungi [30,31].
T53 1443-1632 Sentence denotes Marine algae products have been applied in traditional Chinese herbal medicine for a long time [11], and contain a variety of polysaccharides, including carrageenan, fucoidan, and alginate.
T54 1633-2019 Sentence denotes Carrageenans are sulphated linear polysaccharides composed of repeating disaccharide units with alternating 3-linked β-d-galactopyranose (G-units) and 4-linked α-galactopyranose (D-units) or 3,6-anhydro-α- galactopyranose (AnGal-units) [[32], [33], [34]], which are extracted from certain red algae containing 15–40% ester sulfate with an average molecular weight above 100 kDa [35,36].
T55 2020-2191 Sentence denotes The three commercial most important and widely distributed carrageenans are iota (ι-, G4S-DA2S), kappa (κ-, G4S-DA) and lambda (λ-, G2S-D2S, 6S)-carrageenan (Fig. 3) [37].
T56 2192-2477 Sentence denotes Fucoidan is a fucose-enriched and sulfated polysaccharide extracted from brown algae [11,38], which is composed of L-fucose, sulfate groups and small proportions of D-xylose, D-mannose, D-galactose, and D-glucuronic acid in different sources of brown algae (Fig. 3) [[38], [39], [40]].
T57 2478-2646 Sentence denotes Alginate, an acidic and linear polysaccharide extracted from brown algae, is consisted of alternating β-D-mannuronic acid (M) and α- L-guluronic acid (G) residues [41].
T58 2647-2850 Sentence denotes Polyguluronate sulfate (PGS) (Fig. 3) is a low molecular weight sulfated brown algae polysaccharide obtained by chemical sulfation of polyguluronate (PG) with about 1.5 sulfate per sugar residue [42,43].
T59 2851-3099 Sentence denotes Astragalus polysaccharide (APS) is the most important bioactive component isolated from a Chinese traditional herbal medicine of Astragalus membranaceus, which is composed of glucose, mannose, d-glucose, and D-galactose (Fig. 3) [[44], [45], [46]].
T60 3100-3265 Sentence denotes Radix Isatidis (RI) is also a kind of traditional Chinese herbal medicine with significant antiviral effect, and polysaccharide is its main active component [47,48].
T61 3266-3362 Sentence denotes The polysaccharide from RI is mainly composed of mannose, glucose, galactose and arabinose [49].
T62 3363-3462 Sentence denotes Mushrooms are used as food for long time in China, and also are drugs in the Orient centuries [50].
T63 3463-3592 Sentence denotes Lentinus edodes is one of the most widely edible mushrooms, and is popularly consumed as health foods in Asian countries [50,51].
T64 3593-3824 Sentence denotes Among the bioactive components of mushrooms, the Lentinus edodes polysaccharide (lentinan, LNT) is the most extensively investigated with many immune processes, which is generally described as biological response modifiers [52,53].
T65 3825-3976 Sentence denotes It consists of a β-(1 → 3)-glucan backbone with β-(1 → 6)-glucosyl side-branching units terminated by mannosyl or galactosyl residues (Fig. 3) [50,51].
T66 3977-4080 Sentence denotes Recently, LNT has been widely used as an alternative medicine and dietary supplement in the world [50].