LitCovid-sentences  

PMC:7358770 / 22091-24963 JSONTXT 14 Projects

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Id Subject Object Predicate Lexical cue
T137 0-45 Sentence denotes 3.2 Inhibiting virus adsorption and invasion
T138 46-221 Sentence denotes The first step for virus to invade a cell is to bind to the cell surface by electrostatic interaction or a receptor, such as heparan sulfated proteoglycan on the cell surface.
T139 222-411 Sentence denotes Polysaccharides, especially sulfated polysaccharides, have strong polyanionic properties, and can block the positive charge on the cell surface to prevent virus adsorption or invasion [12].
T140 412-569 Sentence denotes The invasion process of virus is often associated with the endocytosis of virus, the fusion of virus with cell membrane, and the translocation of virus [12].
T141 570-801 Sentence denotes Heparin or heparin-like materials with broad-spectrum antiviral properties [[87], [88], [89]] have been developed to mimic the cell surface carbohydrates responsible for initial viral attachment, such as HS and carrageenan [34,90].
T142 802-963 Sentence denotes The sulfated polysaccharide derived from marine microalga showed strong inhibition against IAV infection via the viral adsorption and internalization steps [91].
T143 964-1111 Sentence denotes The antiviral effect of sulfated polysaccharides from seaweeds was mainly exerted during dengue virus (DENV)-2 adsorption and internalization [92].
T144 1112-1404 Sentence denotes Iota-carrageenan and its N-sulfonated derivatives of poly (allylamine) hydrochloride showed strong antiviral activities against human metapneumovirus (hMPV), a kind of respiratory infections RNA virus, by blocking virus release from the cellular membrane and inhibiting virus adsorption [93].
T145 1405-1522 Sentence denotes Iota-carrageenan also effectively prevents the replication of HRV in primary human nasal epithelial cells in culture.
T146 1523-1647 Sentence denotes The data suggest that iota-carrageenan acts primarily by preventing the binding or the entry of virions into the cells [85].
T147 1648-1759 Sentence denotes Fucoidan can bind to the neuraminidase (NA) of IAV, and inhibit the activity of NA to block the release of IAV.
T148 1760-1938 Sentence denotes Additionally, fucoidan can also interfere with the activation of EGFR, PKCα, NF-κB, and Akt, and inhibit both IAV endocytosis and EGFR internalization in IAV-infected cells [73].
T149 1939-2070 Sentence denotes The antiviral mechanism of the fucoidans may be through blocking herpes simplex virus (HSV)-2 virion adsorption to host cells [94].
T150 2071-2272 Sentence denotes Our team found that 3,6-O-sulfated chitosan (36S) possessed broad anti-HPV activities by directly targeting viral capsid protein and host PI3K/Akt/mTOR pathway to inhibit cell autophagy (Fig. 6 ) [95].
T151 2273-2504 Sentence denotes Interestingly, using HCoV-NL63 as a model system, it can be determined that HTCC polymer blocks the interaction between S protein and cell receptor, consequently blocking its entry into cells and preventing virus infection [68,96].
T152 2505-2670 Sentence denotes The nano/microspheres of N-(2-hydroxypropyl) -3-trimethyl chitosan (HTCC-NS/MS) were used for adsorption of the coronavirus HCoV-NL63 from aqueous virus suspensions.
T153 2671-2803 Sentence denotes This nano/microspheres can be applied for the removal of coronaviruses and purification of water from pathogenic coronaviruses [97].
T154 2804-2872 Sentence denotes Fig. 6 The mechanism of 3,6-O-sulfated chitosan inhibiting HBV [95].