LitCovid-sentences  

PMC:7358770 / 20040-22089 JSONTXT 14 Projects

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Id Subject Object Predicate Lexical cue
T124 0-36 Sentence denotes 3.1 Directly interacting with virus
T125 37-236 Sentence denotes Polysaccharides, especially sulfated polysaccharides, can interact with the surface of virus by negative charge, thereby inhibiting the infectious ability of the virus, or killing the virus directly.
T126 237-431 Sentence denotes Pathogens use GAGs at almost every major entry portal to promote their attachment and invasion of host cells, to move from one cell to another, and to protect themselves from immune attack [22].
T127 432-758 Sentence denotes For example, fucosylated chondroitin sulfate was effective in blocking laboratory strain HIV-1IIIB entry and replication (4.26 μg/mL and 0.73 μg/mL, respectively), and inhibiting infection by clinic isolate HIV-1KM018 and HIV-1TC-2 (23.75 μg/mL and 31.86 μg/mL, respectively) as well as suppressing HIV-1 drug-resistant virus.
T128 759-917 Sentence denotes Further studies indicated that fucosylated chondroitin sulfate can potently bind the recombinant HIV-1 gp120 protein to inhibit several strains of HIV-1 [82].
T129 918-1038 Sentence denotes A cationically modified chitosan derivative, HTCC, has been shown to be an effective inhibitor of HCoV-NL63 replication.
T130 1039-1221 Sentence denotes The analysis of the interaction between HTCC polymer and the recombinant ectodomain of the S protein from CoV showed binding, resulting in the formation of protein-polymer complexes.
T131 1222-1315 Sentence denotes One may assume that such binding will result in the efficient inactivation of the virus [83].
T132 1316-1412 Sentence denotes Carrageenan acts primarily by preventing the binding or the entry of virions into cells [84,85].
T133 1413-1553 Sentence denotes Iota-carrageenan, a high molecular weight sulfated polysaccharide, is an approved antiviral drug that interacts with the viral surface [67].
T134 1554-1652 Sentence denotes The binding and inactivation of virus particles by iota-carrageenan are fast and highly effective.
T135 1653-1819 Sentence denotes During the residence time of the iota-carrageenan containing lozenge in the mouth, the viral titer is reduced by 85% and 91% for IAV and HCoV-OC43, respectively [67].
T136 1820-2049 Sentence denotes Furthermore, animal experiments have shown that iota-carrageenan can reduce the spreading of influenza virus in surface epithelia of infected animals, and thereby provided sufficient benefits for animals to promote survival [86].