LitCovid-sentences  

PMC:7358770 / 14452-17328 JSONTXT 13 Projects

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Id Subject Object Predicate Lexical cue
T91 0-56 Sentence denotes 2.3 Anti-coronavirus activity of marine polysaccharides
T92 57-256 Sentence denotes Marine polysaccharides, such as carrageenan, PGS, chitosan, and their derivatives, show good inhibitory activity against various viruses, which provides a reference for their research on coronavirus.
T93 257-494 Sentence denotes Iota-carrageenan containing lozenges show highly active against human rhinovirus (HRV), influenza virus A H1N1, and HCoV OC43 throughout the entire dissolution process, and are a promising therapy against viral infections of throat [67].
T94 495-930 Sentence denotes The cationically modified chitosan, N-(2-hydroxypropyl)-3-trimethylammonium chitosan chloride (HTCC), shows significant inhibition against the human coronavirus HCoV-229E, HCoV-OC43, HCoV-NL63, and HCoV-HKU1, and its hydrophobically modified derivative (HM-HTCC) is a potent inhibitor of the coronavirus HCoV-NL63, indicating that HTCC polymers based on chitosan are effective inhibitors of all low-pathogenic human coronaviruses [68].
T95 931-1113 Sentence denotes Acute viral upper respiratory tract infection, also known as common cold, is mainly caused by respiratory viruses such as rhinovirus, coronavirus, influenza virus [[69], [70], [71]].
T96 1114-1235 Sentence denotes Clinical trials applying iota-carrageenan nasal spray have shown to reduce the duration of a virus-confirmed common cold.
T97 1236-1459 Sentence denotes Carrageenan nasal spray shows significant antiviral efficacy in three virus subgroups, HRV, human coronavirus, and influenza A virus (IAV), and the highest effectiveness was observed in human corona virus-infected patients.
T98 1460-1663 Sentence denotes The reduced duration of disease was 3 days (p < 0.01), and the number of relapses was three times less (p < 0.01) in carrageenan treated corona-virus -infected patients compared to control patients [70].
T99 1664-1795 Sentence denotes After the outbreak of SARS in 2003, many survivors developed residual pulmonary fibrosis with increased severity in older patients.
T100 1796-1960 Sentence denotes Pulmonary fibrosis is caused by a hyperactive host response to lung injury mediated by epidermal growth factor receptor (EGFR) signaling in animal models (Fig. 5 ).
T101 1961-2089 Sentence denotes Inhibition of EGFR signaling can prevent an excessive fibrotic response to SARS-CoV and other respiratory viral infections [72].
T102 2090-2283 Sentence denotes Moreover, sulfated polysaccharides such as fucoidan and sulfated rhamnan, can interfere or inhibit the expression and activation of EGFR pathway, which may help to suppress coronavirus [73,74].
T103 2284-2445 Sentence denotes The understanding of how polysaccharides play a role in EGFR and other pro-fibrotic pathways after viral infection will provide new ideas for COVID-19 treatment.
T104 2446-2516 Sentence denotes Fig. 5 The illustration about potential role of EGFR in lung fibrosis.
T105 2517-2671 Sentence denotes Physical injury or a pathogen ① initiates the wound healing response by damaging healthy tissue, releasing EGFR ligands ② and activating the EGFR pathway.
T106 2672-2755 Sentence denotes This results in an exaggerated wound healing response leading to a fibrotic lung ③.
T107 2756-2876 Sentence denotes The early use of inhibitors like tyrosine kinase ④ could prevent the normal progress of wound healing and fibrosis [72].