PMC:7358770 / 114-1411 JSONTXT 10 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T3 0-168 Sentence denotes Since the outbreak of the novel coronavirus disease COVID-19, caused by the SARS-CoV-2 virus, it has spread rapidly worldwide and poses a great threat to public health.
T4 169-275 Sentence denotes This is the third serious coronavirus outbreak in <20 years, following SARS in 2002–2003 and MERS in 2012.
T5 276-376 Sentence denotes So far, there are almost no specific clinically effective drugs and vaccines available for COVID-19.
T6 377-544 Sentence denotes Polysaccharides with good safety, immune regulation and antiviral activity have broad application prospects in anti-virus, especially in anti-coronavirus applications.
T7 545-762 Sentence denotes Here, we reviewed the antiviral mechanisms of some polysaccharides, such as glycosaminoglycans, marine polysaccharides, traditional Chinese medicine polysaccharides, and their application progress in anti-coronavirus.
T8 763-960 Sentence denotes In particular, the application prospects of polysaccharide-based vaccine adjuvants, nanomaterials and drug delivery systems in the fight against novel coronavirus were also analyzed and summarized.
T9 961-1193 Sentence denotes Additionally, we speculate the possible mechanisms of polysaccharides anti-SARS-CoV-2, and propose the strategy of loading S or N protein from coronavirus onto polysaccharide capped gold nanoparticles vaccine for COVID-19 treatment.
T10 1194-1297 Sentence denotes This review may provide a new approach for the development of COVID-19 therapeutic agents and vaccines.