LitCovid-sentences  

PMC:7354481 / 45825-49535 JSONTXT 10 Projects

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Id Subject Object Predicate Lexical cue
T292 0-2 Sentence denotes 5.
T293 3-14 Sentence denotes Conclusions
T294 15-92 Sentence denotes Previous epidemics have been caused by betacoronaviruses, especially in Asia.
T295 93-245 Sentence denotes As expected, several similarities and differences in the epidemiology, clinical features, and management of SARS, MERS, and SARS-CoV-19 were seen [114].
T296 246-359 Sentence denotes However, none of the previous infections has caused global pandemics of the scale currently caused by SARS-CoV-2.
T297 360-655 Sentence denotes In our study, analysis of several SARS-CoV-19 genomes, which were isolated from different geographical regions, shows significant similarity scores with human miRs, which target a subset of genes related to pathways affecting virus pathogenicity and host responses observed in COVID-19 patients.
T298 656-810 Sentence denotes The numbers of in silico prediction-based studies that show miRNA mimicking sequences of SARS-CoV-2 genome and miR-mediated host responses are increasing.
T299 811-1067 Sentence denotes It was suggested that, as hsa-miR-4661-3p may target the S gene of SARS-CoV-2, and a virus-encoded miRNA miR147-3p could enhance the expression of TMPRSS2 to promote SARS-CoV-2 infection in the gut, host miRs are critical in the progression of the disease.
T300 1068-1228 Sentence denotes In our current study we identified that seven completely complementary miRNAs of COVID-19 (cc-miRc) prevent viral replication and protein translation processes.
T301 1229-1319 Sentence denotes Similar predictions and biological proofs were determined for MERS and SARS-CoV [115,116].
T302 1320-1537 Sentence denotes By way of comparison to other human coronaviruses, multiple sequence alignment was carried out, comparing the four SARS-CoV-2 sequences with those from SARS, MERS and two cold viruses, OC43 and 229E (Table S3), [115].
T303 1538-1682 Sentence denotes The symptom spectrum for these viruses differ from that of SARS-CoV-2, therefore it is instructive to see if the miR-like sequences are present.
T304 1683-1831 Sentence denotes We identified seven key miRs, which highlight considerable differences between the SARS-CoV-2 sequences, compared with the other viruses (Table S2).
T305 1832-1970 Sentence denotes In each case, the four SARS-CoV-2 sequences are identical, but, for the most part, the level of conservation in the other genomes is poor.
T306 1971-2168 Sentence denotes Across the four sequences, which for SARS generally show the highest degree of conservation: one ‘miR’ is completely conserved (miR-1468), while others range from two to ten nucleotide differences.
T307 2169-2364 Sentence denotes Whilst it is possible that this decrease in similarity could result in reduced levels of transcriptional control, it is clear that there will be a change in the physiological effect of the virus.
T308 2365-2471 Sentence denotes The proposed miR1307 has been suggested as a therapeutic target in the prevention of SARS-CoV-2 infection.
T309 2472-2627 Sentence denotes Therefore, more studies on in silico patterns within the SARS-CoV-2 genome may provide a deeper understanding about miR-based novel therapeutics [117,118].
T310 2628-2779 Sentence denotes MERS shows greater divergence across these segments and the two milder symptom viruses show even greater differences or even significant sequence gaps.
T311 2780-2920 Sentence denotes This divergence away from the SARS-CoV-2 sequences broadly mirrors the phylogenetic relationships obtained from the whole-genome alignments.
T312 2921-3183 Sentence denotes Thus it can be argued that patterns of mutation, occurring during sequence divergence from the longer established human viruses to the more recent ones, have led to the emergence of sequence motifs that can be related directly to the pathogenicity of SARS-CoV-2.
T313 3184-3302 Sentence denotes This mechanism could have considerable significance in determining the symptom spectrum of future potential pandemics.
T314 3303-3480 Sentence denotes KEGG pathway analysis revealed a number of critical pathways linked to the seven identified miRs that may provide insight into the interplay between the virus and comorbidities.
T315 3481-3710 Sentence denotes Based on our reported findings, miRs may constitute a potential and effective therapeutic approach to cure COVID19 infection and its pathological consequences, requiring further validation in large cohort patient-derived samples.