LitCovid-sentences  

PMC:7352545 / 69110-70654 JSONTXT 9 Projects

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Id Subject Object Predicate Lexical cue
T669 0-153 Sentence denotes The emerging CoV-pandemic requires therapeutic agents to block the recognition, binding, replication, amplification and propagation of the CoV in humans.
T670 154-289 Sentence denotes Protease inhibitors, RNA synthase inhibitors and S2 inhibitors are potential targets, and several agents are currently being evaluated.
T671 290-360 Sentence denotes Efficient therapeutic drugs are the most reliable option for patients.
T672 361-497 Sentence denotes The first attachment step of the viral amplification cycle is initiated on the respiratory cell surfaces, driven by the viral S protein.
T673 498-537 Sentence denotes This is a potential therapeutic target.
T674 538-679 Sentence denotes Soon after the SARS-CoV-2 outbreak initiated, the CoV S glycoprotein was demonstrated to recognize ACE2 as a binding receptor on human cells.
T675 680-777 Sentence denotes Human TMPRSS2 enzyme influences the CoV S glycoprotein activation, to facilitate virus infection.
T676 778-864 Sentence denotes ACE2 binding and TMPRSS2 activation facilitate the CoVs to attach to human host cells.
T677 865-978 Sentence denotes Mouse, nonhuman primate and human cells have been analyzed using single-cell RNA new generation sequencing (NGS).
T678 979-1133 Sentence denotes For example, for human infection, CoVs can enter nasal goblet secretory cells, because these cells express the proteins required for SARS-CoV-2 infection.
T679 1134-1224 Sentence denotes In the lungs, the proteins are stored in the alveoli like air sacs of type II pneumocytes.
T680 1225-1301 Sentence denotes In the intestine, the two proteins are expressed in entero-epithelial cells.
T681 1302-1367 Sentence denotes ACE2 gene expression correlates with the IFN-related genes [137].
T682 1368-1418 Sentence denotes ACE2 helps lung cells to tolerate cellular damage.
T683 1419-1544 Sentence denotes Therefore, CoVs may evolutionally take advantage of the defense mechanisms of host cells, hijacking such host-borne proteins.