LitCovid-sentences  

PMC:7352545 / 62119-64185 JSONTXT 12 Projects

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Id Subject Object Predicate Lexical cue
T597 0-6 Sentence denotes 6.3.6.
T598 7-60 Sentence denotes Heparan Sulfate (HS) is the HCoV-NL63 Attachment Site
T599 61-182 Sentence denotes For glycan interaction, HCoV-NL63 and MHV utilize heparan sulfate proteoglycans (HSPGs) as attachment enhancers [87,124].
T600 183-231 Sentence denotes Viruses recognize HSPGs as attachment molecules.
T601 232-306 Sentence denotes In the spike (S) protein-deficient virions, the M protein recognizes HSPG.
T602 307-368 Sentence denotes The S proteins generally bind to the viral cellular receptor.
T603 369-457 Sentence denotes However, the M protein also acts as a receptor in the early step of HCoV-NL63 infection.
T604 458-534 Sentence denotes The M membrane protein of HCoV-NL63 recognizes the attachment site of HSPGs.
T605 535-711 Sentence denotes HCoV-NL63 M protein binds to HSPG for the initial attachment of virus to host cells and thereafter, the M and S proteins cooperate for virus entrance into the host cells [125].
T606 712-820 Sentence denotes HSPGs are glycosaminoglycan (GAG)-carrying proteins frequently used as a secondary receptor for viral entry.
T607 821-883 Sentence denotes HSPGs are composed of covalent-bonded HS chains as a GAG form.
T608 884-987 Sentence denotes The HS GAG linkage structure of tetrasaccharide exhibits GluAβ1,3GlcNAcα1,4Galβ1,3Galβ1,4Xylβ-O-serine.
T609 988-1174 Sentence denotes Glycosyltransferases involved in HS GAG synthesis include GlcAT-II (glucuronosyltransferase) and GlcNAcT-II (N-acetylglucosaminyltransferase II) for heparan sulfate synthesis (Figure 9).
T610 1175-1253 Sentence denotes GAG is used as docking sites for virus interaction with the host cell surface.
T611 1254-1317 Sentence denotes GAGs contain negatively charged N- and O-sulfated sugars [126].
T612 1318-1509 Sentence denotes The biosynthetic pathway and biologic roles in early embryogenic morphogenesis and vulval morphogenesis of HS and chondroitin sulfate GAG have been elucidated in Caenorhabditis elegans [127].
T613 1510-1610 Sentence denotes The negative charges mediate the interaction of GAGs and their ligands through electrostatic forces.
T614 1611-1685 Sentence denotes Interaction of HSPG with ligands potentiates many virus infectious cycles.
T615 1686-1958 Sentence denotes For examples, adeno-associated virus, human T cell lymphotropic virus type 1, human papilloma virus 16, herpes viruses, hepatitis B and C viruses, Kaposi’s sarcoma-associated herpesvirus, human papilloma viruses and Merkel cell polyoma virus recognize the HSPGs [128,129].
T616 1959-2066 Sentence denotes HSPGs increase virulence upon interaction with viral factors required for viral attachment and replication.