LitCovid-sentences  

PMC:7352545 / 28686-32535 JSONTXT 11 Projects

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Id Subject Object Predicate Lexical cue
T283 0-4 Sentence denotes 5.2.
T284 5-39 Sentence denotes Substrate Diversity of the CoV HEs
T285 40-117 Sentence denotes HEs as envelope proteins are found in CoVs, orthomyxoviruses and toroviruses.
T286 118-181 Sentence denotes Coronaviral HEs are involved in virus attachment to SA species.
T287 182-290 Sentence denotes HE protein in β-CoVs binds to Neu5,9Ac2 form SA and agglutinates the red blood cells (RBCs) of rodents [52].
T288 291-404 Sentence denotes As with SA-O-acetylesterase, HE potentiates viral entry with the S protein and spreading via the mucosal glycans.
T289 405-473 Sentence denotes It contains a carbohydrate-recognizing domain (CRD) known in lectin.
T290 474-556 Sentence denotes The HE glycan-binding domain (GBD) mediates virus attachment to SAs on host cells.
T291 557-575 Sentence denotes HE is the only HA.
T292 576-709 Sentence denotes This indicates that compared to the S glycoprotein, HE is only minor a HA and the S glycoprotein mainly attaches to the cell surface.
T293 710-932 Sentence denotes The HE protein of murine hepatitis virus (MHV), an enveloped CoV, binds to SA-4-acetylester or SA-9-O-acetylester of the carcinoembryonic antigen cell adhesion molecule 1a (CEACAM; known as CD66a) as the key receptor [53].
T294 933-1010 Sentence denotes Murine CoVs HEs acquired by horizontal gene transfer, bind to C9-O-Ac Neu5Ac.
T295 1011-1070 Sentence denotes However, some murine CoV HEs cannot bind to C4-O-Ac Neu5Ac.
T296 1071-1221 Sentence denotes The original mouse MHV HE binds to C9-O-Ac Neu5Ac, while the MHV S-strain HE evolutionarily acquired the ability to bind to C4-O-Ac Neu5Ac [12,53,54].
T297 1222-1373 Sentence denotes In terms of structure, the C5 N- and C9 O-Ac Neu5Ac-accomodating hydrophobic pocket was shifted to a C5 N- and C4-O-Ac Neu5Ac-accomodating pocket [55].
T298 1374-1436 Sentence denotes Type I HE is specific for the 9-O-acetylated SAs (9-O-Ac-SAs).
T299 1437-1475 Sentence denotes Type II HE is specific for 4-O-Ac-SAs.
T300 1476-1600 Sentence denotes The SA-binding shift indicates quasi-synchronous adaptations of the SA-recognition sites of the lectin and esterase domains.
T301 1601-1736 Sentence denotes Type I HE monomers of β-CoV lineage A have a bimodular enzyme–lectin domain similar to cellular glycan/carbohydrate-modifying proteins.
T302 1737-1941 Sentence denotes Originally, HE homologs are found in various viruses including toroviruses and orthomyxoviruses such as the influenza virus C/D and isavirus, as well as the exceptional case of β-CoV lineage A among CoVs.
T303 1942-2098 Sentence denotes The HE gene was transmitted to a β-CoV lineage A progenitor via horizontal gene transfer from a 9-O-Ac-Sia–recognizing HEF, as shown in influenza virus C/D.
T304 2099-2274 Sentence denotes HE acquisition and expansion occurred by cross-species transmission over HE evolution and this phenomenon reflects viral evolutionary adaptation to host SA-containing glycans.
T305 2275-2387 Sentence denotes Therefore, CoV HE receptor switching precedes virus evolution driven by SA-containing glycan diversity of hosts.
T306 2388-2489 Sentence denotes For instance, the BcoV HE prefers 7,9-di-O-Ac-SAs, which is also a target of the bovine torovirus HE.
T307 2490-2633 Sentence denotes For a more outstanding case, such a switching event occurred in the murine CoVs for the β-CoV lineage A type switch toward O-Ac-SA recognition.
T308 2634-2878 Sentence denotes In the HE specificity of murine CoVs, two different murine CoV subtypes of virus group exist with one subtype possessing the typical 9-O-Ac-SA (type I) attachment factor and the other exclusively 4-O-Ac-SA (type II) attachment virus group [56].
T309 2879-3068 Sentence denotes The first coronaviral HE proteins identified were from the porcine hemagglutinating encephalomyelitis virus (PHEV), BCoV and HCoV-OC43, which bear SA-9-O-acetylesterases similar to HEF [8].
T310 3069-3154 Sentence denotes Rat CoV (RCoV) has SA-4-O-acetylesterases, converting Neu4,5Ac2 to Neu5Ac [53,57,58].
T311 3155-3212 Sentence denotes Some murine CoVs prefer 4-O-Ac-SAs and others 9-O-Ac-SAs.
T312 3213-3294 Sentence denotes HCoV-OC43 and BCoV prefer α2-6-SA 9-O-acetylation by their SA-O-acetyleseterases.
T313 3295-3467 Sentence denotes The S glycoproteins of BCoV and HCoV-OC43 are Neu5,9Ac2-recognizing lectins and agglutinate murine, rat and chicken erythrocytes due to the enriched 9-O-Ac-SA species [52].
T314 3468-3551 Sentence denotes BCoV and HCoV-OC43 adapted to SA receptor determinants of 9-O-Ac-SA receptors [59].
T315 3552-3661 Sentence denotes For a second receptor, the binding of S glycoprotein to Neu5,9Ac2 receptor is essential for entry into cells.
T316 3662-3849 Sentence denotes BCoV-infection is prevented by prior treatment of cells with NA enzyme or with viral SA-O-acetylesterases, blocking the roles of HE and S glycoprotein in SA-dependent entry to host cells.