LitCovid-sentences  

PMC:7352545 / 14469-15729 JSONTXT 8 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T126 0-4 Sentence denotes 3.1.
T127 5-41 Sentence denotes Spike (S) Transmembrane Glycoprotein
T128 42-82 Sentence denotes In RNA viruses, the S glycoprotein (PDB:
T129 83-232 Sentence denotes 6VSB) is the biggest protein, heavily glycosylated and its N-terminal domain (NTD) sequence binds to the host receptor to enter the ER of host cells.
T130 233-302 Sentence denotes SARS-CoV-2 S-glycoprotein bears 22 N-glycan sequons in each protomer.
T131 303-379 Sentence denotes Therefore, the trimeric S glycoprotein surface is dominated by 66 N-glycans.
T132 380-488 Sentence denotes The S glycoprotein mediates direct and indirect interaction of virus with host cells in the infection cycle.
T133 489-578 Sentence denotes All CoVs exhibit a surface S glycoprotein, which bears the receptor-binding domain (RBD).
T134 579-629 Sentence denotes The S glycoprotein has a distinct spike structure.
T135 630-828 Sentence denotes When S glycoprotein binds to its host receptor, a host furin-like protease cleaves the S glycoprotein, which liberates the spike fusion peptides, allowing entry of the virus into the host cell [18].
T136 829-1006 Sentence denotes The furin-like protease-generated S1 and S2 exist as a S1/S2 complex, where S1 in a homotrimeric form interacts with the host cell membrane and S2 penetrates the cytosolic area.
T137 1007-1125 Sentence denotes For SARS-CoV and MERS-CoV, the S1 C-terminal domains (CTDs) have a dual role in virus entry via attachment and fusion.
T138 1126-1207 Sentence denotes The S1 NTD binds to carbohydrate receptors because the S1 domains act as the RBD.
T139 1208-1260 Sentence denotes The CTD of S1 recognizes protein receptors via RBDs.