| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T52 |
0-173 |
Sentence |
denotes |
An emerging body of evidence supports therefore an increased systemic inflammatory reaction in patients with severe SARS-CoV-2 infection who are more likely to develop CAPA. |
| T53 |
174-360 |
Sentence |
denotes |
In this regard, increased levels of circulating proinflammatory cytokines, such as TNF, were observed in patients requiring intensive care, compared to those with milder infections [35]. |
| T54 |
361-552 |
Sentence |
denotes |
Other studies, however, have also unveiled marked defects in immune cell populations, namely T-lymphocytes, as another factor explaining the immune dysfunction in patients with COVID-19 [36]. |
| T55 |
553-708 |
Sentence |
denotes |
This suggests that while sustained innate immune function leads to hyperinflammation [37], lymphocyte numbers decline, and their function may be defective. |
| T56 |
709-896 |
Sentence |
denotes |
In this regard, severe lymphocytopenia was among the factors in a risk score model that predicted the development of invasive mold disease in patients with hematological malignances [38]. |
| T57 |
897-1252 |
Sentence |
denotes |
It is thus reasonable to speculate that in elderly individuals or with co-morbidities, defective immune responses to SARS-CoV-2 may allow unrestricted viral replication which, in turn, elicits hyperinflammation and severe complications such as ARDS [39], besides establishing favorable conditions for the acquisition of secondary infections, such as CAPA. |
