PMC:7346000 / 31903-38814 JSONTXT 11 Projects

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Id Subject Object Predicate Lexical cue
T174 0-223 Sentence denotes Country (Prevalence) COHORT [Ref] Age/Sex Underlying Conditions CAPA Classification Local/Systemic Corticosteroid Use GM (ODI)/Serum BDG (pg/mL)/qPCR Species (Voriconazole Susceptibility Pattern) Treatment # Outcome
T175 224-538 Sentence denotes Germany (5/19; 26.3%)ARDS [50] 62/F Cholecystectomy for cholecystitis, arterial hypertension, obesity with sleep apnea, hypercholesterolemia, ex-smoker, COPD (GOLD 2) Putative Inhaled steroids for COPD GM Serum negative GM BALF> 2.5 qPCR BALF = Positive Aspergillus fumigatus (S) culture from BALF VCZ Died
T176 539-730 Sentence denotes 70/M Vertebral disc prolapse left L4/5, flavectomy and nucleotomy, Ex-smoker Putative No GM Serum = 0.7 GM BALF> 2.5 qPCR BALF = Positive A. fumigatus by PCR; negative culture ISA Died
T177 731-1014 Sentence denotes 54/M Arterial hypertension, diabetes mellitus, aneurysm coiling right A. vertebralis Putative Intravenous corticosteroid therapy 0.4 mg/kg/d, total of 13 days) GM Serum negative GM BALF> 2.5 qPCR BALF = Positive A. fumigatus (S) culture from tracheal aspirate CASPO→ VCZ Alive
T178 1015-1257 Sentence denotes 73/M Arterial hypertension, bullous emphysema, smoker, COPD (GOLD 3), Previous Hepatitis B Putative Inhaled steroids for COPD GM Serum negative qPCR tracheal secretion = Positive A. fumigatus (S) culture from tracheal aspirate VCZ Died
T179 1258-1378 Sentence denotes 54/F None Putative No GM Serum = 1.3 and 2.7 qPCR tracheal secretion = Negative Negative culture CASPO→ VCZ Alive
T180 1379-1668 Sentence denotes France (9/27; 33.3%)ARDS * [51] 53/M Hypertension, obesity, ischemic heart disease Putative Dexamethasone iv 20 mg once daily from day 1 to day 5, followed by 10 mg once daily from day 6 to day 10 GM Serum = 0.13 GM BALF = 0.89 BDG = 523 qPCR = Negative Negative culture None Alive
T181 1669-1814 Sentence denotes 59/F Hypertension, obesity, diabetes Putative No GM Serum = 0.04 GM BALF = 0.03 qPCR = Negative A. fumigatus, culture from BALF None Alive
T182 1815-2062 Sentence denotes 69/F Hypertension, obesity Putative Dexamethasone iv 20 mg once daily from day 1 to day 5, followed by 10 mg once daily from day 6 to day 10 GM Serum = 0.04 BDG = 7.8 qPCR BALF = 23.9 A. fumigatus, culture from tracheal secretion None Alive
T183 2063-2301 Sentence denotes 63/F Hypertension, diabetes, ischemic heart disease Putative Dexamethasone iv 20 mg once daily from day 1 to day 5, followed by 10 mg once daily from day 6 to day 10 GM Serum = 0.51GM BALF = 0.15 BDG = 63 Negative culture None Died
T184 2302-2455 Sentence denotes 43/M Asthma with steroid use history Putative No GM Serum = 0.04 GM BALF = 0.12 BDG = 7 qPCR = Negative A. fumigatus, culture from BALF None Alive
T185 2456-2694 Sentence denotes 79/M Hypertension Putative Dexamethasone iv 20 mg once daily from day 1 to day 5, followed by 10 mg once daily from day 6 to day 10 GM Serum = 0.02 GM BALF = 0.05 BDG = 23 qPCR BALF = 34.5 A. fumigatus, culture from BALF None Alive
T186 2695-2938 Sentence denotes 77/M Hypertension, asthma Putative Dexamethasone iv 20 mg once daily from day 1 to day 5, followed by 10 mg once daily from day 6 to day 10 GM Serum = 0.37 GM BALF = 3.91 BDG = 135 qPCR BALF = 29 A. fumigatus, culture from BALF VCZ Died
T187 2939-3188 Sentence denotes 75/F Hypertension, diabetes Putative Dexamethasone iv 20 mg once daily from day 1 to day 5, followed by 10 mg once daily from day 6 to day 10 GM Serum = 0.37 GM BALF = 0.36 BDG = 450 qPCR BALF = 31.7 A. fumigatus, culture from BALF CASPO Died
T188 3189-3331 Sentence denotes 47/M Multiple myeloma with steroid therapy Probable No GM Serum = 0.09 BDG = 14 A. fumigatus, culture from tracheal secretion None Died
T189 3332-3549 Sentence denotes Netherlands (6/31; 19.4%)ARDS [47] 83/M Cardiomyopathy Possible Prednisolone 0ꞏ13mg/kg/day for 28 dayspre-admission GM Serum = 0.4 A. fumigatus, culture from tracheal aspirate VCZ + ANID (5/6) L-AmB (1/6) Died
T190 3550-3708 Sentence denotes 67/M COPD (GOLD 3), Post RTx NSCLC 2014 Possible Prednisolone 0ꞏ37mg/kg/day for 2 dayspre-admission NA A. fumigatus, culture from tracheal aspirate Died
T191 3709-3797 Sentence denotes 75/M COPD (GOLD 2a) Probable No GM BALF = 4.0 A. fumigatus, culture from BALF Died
T192 3798-3863 Sentence denotes 43/M None Probable No GM Serum = 0.1 GM BALF = 3.8 NA Alive
T193 3864-4020 Sentence denotes 57/M Bronchial asthma Probable Fluticasone 1ꞏ94 mcg/kg/day for 1 month pre-admission GM Serum = 0.1 GM BALF = 1.6 A. fumigatus. culture from BALF Died
T194 4021-4099 Sentence denotes 58/M None Possible No NA Aspergillus spp. (S), culture from sputum Alive
T195 4100-4234 Sentence denotes Belgium (7/20; 35%)ARDS [52] 86/M Hypercholesterinemia NA No GM serum = 0.1 A. flavus culture from tracheal aspirate None Died
T196 4235-4361 Sentence denotes 38/M Obesity, hypercholesterinemia Proven No GM serum = 0.3 GM BALF > 2.8 A. fumigatus culture from BALF VCZ, ISA Alive
T197 4362-4459 Sentence denotes 62/M Diabetes Proven No GM serum = 0.2 GM BALF = 2 A. fumigatus culture from BALF VCZ Died
T198 4460-4604 Sentence denotes 73/M Diabetes, obesity, hypertension, hypercholesterinemia Proven No GM serum= 0.1 GM BALF > 2.8 A. fumigatus culture from BALF VCZ Alive
T199 4605-4770 Sentence denotes 77/M Diabetes, chronic kidney disease, hypertension, pemphigus foliaceus Proven Yes, ND GM serum = 0.1 GM BALF = 2.79 A. fumigatus culture from BALF VCZ Alive
T200 4771-4890 Sentence denotes 55/M HIV, hypertension, hypercholesterinemia NA No GM serum = 0.80 GM BALF = 0.69 Negative culture VCZ, ISA Died
T201 4891-4986 Sentence denotes 75/M Acute myeloid leukemia NA No GM BALF = 2.63 A. fumigatus culture from BALF VCZ Died
T202 4987-5399 Sentence denotes France (1)ARDS [57] 74/M Myelodysplastic syndrome, CD8 + T-cell lymphocytosis, Hashimoto’s thyroiditis, hypertension, benign prostatic hypertrophy Putative No First GM on tracheal secretion = Negative First qPCR = Positive Second GM tracheal secretion = NA Second qPCR = Positive Direct smear of the second sample = branched septate hyphae A. fumigatus, culture of the second tracheal secretion None Died
T203 5400-5561 Sentence denotes France (1/5; 20%)Mixed ICU [58] 80/M Thyroid cancer (patient presented with ARDS) Putative NA No A. flavus, culture from tracheal secretion VCZ→ ISA Died
T204 5562-5780 Sentence denotes Italy (1)ARDS [59] 73/M Diabetes, hypertension, obesity, hyperthyroidism, atrial fibrillation Proven No GM Serum = 8.6 qPCR from paraffin block tissue = Positive A. fumigatus, culture from BALF L-AmB → ISA Died
T205 5781-6161 Sentence denotes Austria (1)ARDS [60] 70/M COPD (GOLD 2), obstructive sleep apnea syndrome, insulin-dependent type 2 diabetes with end organ damage, arterial hypertension, coronary heart disease, and obesity Putative Inhaled Budesonide (400 mg per day) GM Serum = Negative BDG = Negative LFD Positive from endotracheal aspiration A. fumigatus, culture from endotracheal aspiration VCZ Died
T206 6162-6302 Sentence denotes Germany (2)ARDS [61] 80/M Suspected pulmonary fibrosis ND No GM Serum = 1.5 GM BALF = 6.3 A. fumigatus, culture from BALF L-AmB Died
T207 6303-6402 Sentence denotes 70/M None ND No GM Serum = Negative GM BALF = 6.1 A. fumigatus, culture from BALF L-AmB Died
T208 6403-6717 Sentence denotes Netherlands (1)ARDS [62] 74/F Polyarthritis, reflux, stopped smoking 20 years ago Putative No GM serum = Persistently < 0.5 GM tracheal aspirate = >3 BDG serum = 1590 A. fumigatus, culture from tracheal aspirate (R)TR34/L98HICZ = 16µg/mL, VCZ = 2µg/mL, and POSA = 0.5µg/ml VCZ + CASPO→ Oral VCZ→ L-AmB Died
T209 6718-6911 Sentence denotes Australia (1) ARDS [63] 66/F Hypertension, osteopenia, ex-smoker (20 pack years) Putative No N/A A. fumigatus culture from tracheal aspirate (3x) VCZ + Therapeutic Drug monitoring Alive