LitCovid-sentences  

PMC:7341464 / 119-8522 JSONTXT 12 Projects

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Id Subject Object Predicate Lexical cue
T3 0-14 Sentence denotes To the Editor:
T4 15-143 Sentence denotes We read with interest the article by Li et al. first to report on COVID-19 in patients with chronic myeloid leukaemia (CML) [1].
T5 144-306 Sentence denotes They found an increased COVID-19 prevalence in CML patients of the Hubei region in China when compared to the prevalence of the general population of that region.
T6 307-428 Sentence denotes Unfortunately, in this retrospective study, follow-up data were not provided and a direct control group was not included.
T7 429-757 Sentence denotes We report preliminary results of a prospective Dutch observational cohort study that assessed differences in susceptibility for COVID-19 and severity of the disease course in adult CML patients and their adult housemates during the SARS-CoV2 pandemic (the first COVID-19 case was identified on February 27th in the Netherlands).
T8 758-901 Sentence denotes Patients were invited to participate via CMyLife [2], a nationwide web-based portal focused on Dutch CML patients, from April 6th 2020 onwards.
T9 902-1047 Sentence denotes If available, their adult housemates (e.g., spouses) were included as control group, providing a better representation of the general population.
T10 1048-1118 Sentence denotes Surveys were performed at baseline and at a 2-weekly follow-up period.
T11 1119-1235 Sentence denotes CML patients receiving TKI treatment or having a discontinuation of their TKI treatment were invited to participate.
T12 1236-1382 Sentence denotes The study was approved by the Radboudumc institutional ethics committee and digital informed consent was obtained from both patients and partners.
T13 1383-1635 Sentence denotes At inclusion, information was gathered on demographics, self-reported comorbidity, vaccinations, health rating, COVID-19 related symptoms and hospital admissions and additional for patients; CML course, patients’ perceptions regarding CML and COVID-19.
T14 1636-1801 Sentence denotes Every 2 weeks a truncated shorter version of the questionnaire was conducted, focusing on TKI intake, preventive measures, testing, symptoms and hospital admissions.
T15 1802-2048 Sentence denotes At time of submission, 167 patients have registered for the study and 148 CML patients (median age, 57.5 years; range 26–82 years; 48% males) and 123 housemates (median age 60 years, range 24–88 years) were included, with enrolment still ongoing.
T16 2049-2117 Sentence denotes The baseline characteristics are presented in Supplementary Table 1.
T17 2118-2161 Sentence denotes The majority (88.4%) had taken TKI therapy.
T18 2162-2269 Sentence denotes Approximately half of the CML patients versus a third of controls had comorbidity that required medication.
T19 2270-2375 Sentence denotes The annual influenza vaccination was received by 58.0% of the CML patients and 35.8% of their housemates.
T20 2376-2530 Sentence denotes If a coronavirus vaccine would become available, both patients and their housemates would be largely willing to take this (76.3% and 68.9%, respectively).
T21 2531-2684 Sentence denotes The majority applied preventive measures as recommended by national institutes (e.g., not shaking hands, frequently washing hands and social distancing).
T22 2685-2747 Sentence denotes Patients’ perceptions regarding COVID-19 are shown in Table 1.
T23 2748-2816 Sentence denotes Table 1 Reported perceptions of patients on COVID-19 related to CML.
T24 2817-2835 Sentence denotes Patients (N = 148)
T25 2836-2841 Sentence denotes % (n)
T26 2842-2898 Sentence denotes Thinks to be more susceptible to COVID-19 because of CML
T27 2899-2914 Sentence denotes   Yes 32.4 (48)
T28 2915-2929 Sentence denotes   No 35.8 (53)
T29 2930-2953 Sentence denotes   Do not know 31.8 (47)
T30 2954-3007 Sentence denotes Thinks COVID-19 course will be more severe due to CML
T31 3008-3023 Sentence denotes   Yes 35.8 (53)
T32 3024-3038 Sentence denotes   No 20.3 (30)
T33 3039-3062 Sentence denotes   Do not know 43.9 (65)
T34 3063-3092 Sentence denotes Worries about the coronavirus
T35 3093-3113 Sentence denotes   Not at all 5.4 (8)
T36 3114-3134 Sentence denotes   A little 54.7 (81)
T37 3135-3158 Sentence denotes   Quite a bit 30.4 (45)
T38 3159-3179 Sentence denotes   Very much 9.5 (14)
T39 3180-3256 Sentence denotes Next we analysed symptoms of patients and housemates at inclusion (Table 2).
T40 3257-3371 Sentence denotes Among patients, rhinitis was the most reported symptom (16.9%), followed by coughing (14.2%) and dyspnoea (10.8%).
T41 3372-3395 Sentence denotes Fever was not reported.
T42 3396-3446 Sentence denotes Many (69.6%) patients reported to be symptom free.
T43 3447-3566 Sentence denotes Among the housemates, rhinitis was reported in 8.9% of cases, and coughing and dyspnoea in 6.5% and 2.4%, respectively.
T44 3567-3597 Sentence denotes Again, fever was not reported.
T45 3598-3651 Sentence denotes The majority (84.6%) reported to be free of symptoms.
T46 3652-3823 Sentence denotes Only two patients had been tested for SARS-CoV2 at study inclusion, of whom one tested positive and reported to have been admitted to the hospital (without ICU admission).
T47 3824-3946 Sentence denotes This patient was a 62 year male without comorbidity, who received imatinib therapy since the CML diagnosis 2 years before.
T48 3947-4010 Sentence denotes No housemates were tested nor reported any hospital admissions.
T49 4011-4137 Sentence denotes Table 2 Information on preventive measures, symptoms and hospital admissions related to COVID-19 in CML patients at inclusion.
T50 4138-4177 Sentence denotes Patients (N = 148) Housemates (N = 124)
T51 4178-4189 Sentence denotes % (n) % (n)
T52 4190-4228 Sentence denotes Visited affected areaa 3.4 (5) 4.1 (5)
T53 4229-4249 Sentence denotes Preventive measuresb
T54 4250-4262 Sentence denotes   None 0 N/A
T55 4263-4299 Sentence denotes   Avoid shaking hands 85.1 (126) N/A
T56 4300-4334 Sentence denotes   Clean hands often 84.5 (125) N/A
T57 4335-4365 Sentence denotes   Use of face mask 2.7 (4) N/A
T58 4366-4433 Sentence denotes   Working from home, just as same-function colleagues 31.8 (47) N/A
T59 4434-4507 Sentence denotes   Working from home, in contrary to same-function colleagues 6.8 (10) N/A
T60 4508-4538 Sentence denotes   Self-isolation 41.2 (61) N/A
T61 4539-4560 Sentence denotes   Other 14.9 (22) N/A
T62 4561-4570 Sentence denotes Symptomsb
T63 4571-4600 Sentence denotes   Rhinitis 16.9 (25) 8.9 (11)
T64 4601-4629 Sentence denotes   Coughing 14.2 (21) 6.5 (8)
T65 4630-4659 Sentence denotes   Sore throat 4.1 (6) 2.4 (3)
T66 4660-4688 Sentence denotes   Dyspnoea 10.8 (16) 2.4 (3)
T67 4689-4708 Sentence denotes   Fever 0 (0) 0 (0)
T68 4709-4744 Sentence denotes   No symptoms 69.6 (103) 84.6 (104)
T69 4745-4762 Sentence denotes SARS-CoV2 testing
T70 4763-4793 Sentence denotes   Tested, positive 0.7 (1) 0.0
T71 4794-4824 Sentence denotes   Tested, negative 0.7 (1) 0.0
T72 4825-4858 Sentence denotes   Not tested 98.0 (145) 100 (123)
T73 4859-4878 Sentence denotes   Unknown 0.7 (1) 0
T74 4879-4914 Sentence denotes Hospital admissionc 0.7 (1) 0.0 (0)
T75 4915-4962 Sentence denotes   Intensive Care Unit admission 0.0 (0) 0.0 (0)
T76 4963-5002 Sentence denotes Lives with adult housemate 85.9 (128) –
T77 5003-5018 Sentence denotes N = 131 N = 106
T78 5019-5030 Sentence denotes % (n) % (n)
T79 5031-5039 Sentence denotes Vaccines
T80 5040-5069 Sentence denotes  Annual influenza vaccination
T81 5070-5095 Sentence denotes   Yes 58.0 (76) 35.8 (38)
T82 5096-5120 Sentence denotes   No 42.0 (55) 64.1 (68)
T83 5121-5161 Sentence denotes  If available, would take corona vaccine
T84 5162-5189 Sentence denotes    Yes 76.3 (100) 68.9 (73)
T85 5190-5211 Sentence denotes    No 3.8 (5) 0.9 (1)
T86 5212-5246 Sentence denotes    Do not know 19.8 (26) 30.2 (32)
T87 5247-5365 Sentence denotes aAffected areas with high risk of COVID-19 as established by National Institute for Public Health and the Environment:
T88 5366-5454 Sentence denotes Italy, Austria, Nordrhein Westfalen (Germany), Madrid (Spain), China, South Korea, Iran.
T89 5455-5482 Sentence denotes bMultiple answers possible.
T90 5483-5574 Sentence denotes cHospital/ICU admission because of the following symptoms: coughing, dyspnoea and/or fever.
T91 5575-5696 Sentence denotes Currently, most subjects have completed their first and second 2-weekly follow-up questionnaires (Supplementary Table 2).
T92 5697-5752 Sentence denotes No patients reported (temporarily) TKI discontinuation.
T93 5753-5882 Sentence denotes A further six persons (two patients and four housemates) were tested for SARS-CoV2 during this follow-up and all tested negative.
T94 5883-5920 Sentence denotes No hospital admissions were reported.
T95 5921-6078 Sentence denotes At 2 weeks, 74.2% (n = 95) of the patients reported to be free of symptoms, compared to 79.4% (n = 100) and 88.9% (n = 16) at four and 6 weeks, respectively.
T96 6079-6175 Sentence denotes For housemates these rates were 87.6% (n = 106), 91.6% (n = 98) and 100% (n = 15), respectively.
T97 6176-6264 Sentence denotes To conclude, we found no significantly increased prevalence of COVID-19 in CML patients.
T98 6265-6358 Sentence denotes Only one patient (0.7%) reported to be tested positive and has been admitted to the hospital.
T99 6359-6531 Sentence denotes These findings are important for CML patients and professionals (prescribers of TKI) as almost 40% of patients reported to be substantially concerned about the coronavirus.
T100 6532-6735 Sentence denotes The prevalence rate is in line with the reported 0.3% in the general Dutch population [3], and with the reported low prevalence of <1% SARS-CoV2 viral infections in CML patients in the study of Li et al.
T101 6736-6892 Sentence denotes We included a representative control cohort of housemates of similar age and geographical spreading as the patients, of whom none were tested positive (0%).
T102 6893-7125 Sentence denotes Similar to Li et al. (0.9% vs 0.1%), we did find a slightly higher percentage of infected patients than in the general population (0.7% vs 0.3%) based on PCR testing on clinical indication, but this is not statistically significant.
T103 7126-7222 Sentence denotes Other studies focusing primarily on COVID-19 infection prevalence in CML population are lacking.
T104 7223-7272 Sentence denotes There are strengths and limitations to our study.
T105 7273-7594 Sentence denotes Although there may have been some self-selection bias in our study, the recruitment through the national CMyLife digital patient platform did allow for a substantial and geographically nationwide spread of participants, also in a time when many patients isolated themselves and hospital visits were limited when possible.
T106 7595-7669 Sentence denotes Also, our study was performed prospectively, and included a control group.
T107 7670-7812 Sentence denotes Furthermore, our questionnaires focused on patients’ perceptions, offering insights in the substantial level of anxiety in this patient group.
T108 7813-7898 Sentence denotes However, the number of SARS-CoV2 tested subjects was low, limiting statistical power.
T109 7899-8132 Sentence denotes Taken together, the report by Li et al. and our current data may offer relief to CML patients in general that the absolute risk of contracting a serious SARS-CoV2 infection in CML patients, was low (<1%) during the COVID-19 pandemic.
T110 8133-8330 Sentence denotes However, as we did observe more upper airway symptoms and further research should focus on serological testing in the CML population to objectively assess subclinical COVID-19 infection prevalence.
T111 8331-8403 Sentence denotes Finally, our study supports that patients can safely continue their TKI.