LitCovid-sentences  

PMC:7335631 / 4949-8572 JSONTXT 10 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T40 0-157 Sentence denotes Among these virus genomes from 3617 patients; 2588 were from the USA, 372 were from Asia, 287 were from Europe, 365 were from Oceania and 5 were from Africa.
T41 158-282 Sentence denotes Here, we present the non-synonymous mutations of the E-protein protein over the available 3617 SARS-CoV2 genomes (Table 1 ).
T42 283-511 Sentence denotes It is to be noted that 10 (0.386%) out of 2588 genomes from USA, 3 (0.806%) from Asia, 1 (0.348%) from Europe and 1 (0.274%) from Oceania) contained the missense mutations (Table 1) in the envelope proteins of SARS-CoV2 genomes.
T43 512-610 Sentence denotes Changes of the R-group of each amino acid according to the mutations are also presented (Table-1).
T44 611-896 Sentence denotes It is to be noted that the mutation of an amino acid A 1 to an amino acid A 2 is denoted by A 1 pA 2 where p denotes location in the reference amino acid sequence.• In less than 0.5% of the SARS-CoV2 genomes, the E-protein possesses the missense mutations as adumbrated in the Table 1.
T45 897-997 Sentence denotes In TMD and C-terminus domain, there are nine different mutations where the R-group property changes.
T46 998-1138 Sentence denotes But only in QHZ00381, for the mutation L37H in the TMD of the envelope protein causes changes in amino acid from hydrophobic to hydrophilic.
T47 1139-1334 Sentence denotes • TMD was also observed to be conserved over the SARS-CoV1 and COV2 genomes, but the protein sequences of QJA42107 (USA: VA), QJQ84222(USA: KENNER, LA), QHZ00381(South Korea) and QJS53352(Greece:
T48 1335-1442 Sentence denotes Athens) possess four mutations A36V, L26F, L37H and L39M, respectively, in the TMD of the envelope protein.
T49 1443-1631 Sentence denotes Change in the R-group property from Hydrophobic to Hydrophilic in the TMD of the envelope protein of the virus from South Korea may affect the ion channel activity of the envelope protein.
T50 1632-1725 Sentence denotes • The motif ′DLLV′ has been changed to ′DFLV′ and ′YLLV′ in the proteins QJR88103 (Australia:
T51 1726-1756 Sentence denotes Victoria) and QKI36831 (China:
T52 1757-1816 Sentence denotes Guangzhou) due to the mutations L73F and D72Y respectively.
T53 1817-2007 Sentence denotes These mutations having changes in the motif ′DFLV′ may mis-target the PALS1 at Golgi and delaying TJ formation and accordingly may influence replication and/or infectivity of the virus [10].
T54 2008-2185 Sentence denotes • In the C-terminus domain of the E-protein of SARS-CoV2 the amino acid S at 68th position changes to the amino acids F and C in the proteins {QKG87268,  QKG88576} from the USA:
T55 2186-2224 Sentence denotes Massachusetts and QKI36855 from China:
T56 2225-2248 Sentence denotes Guangzhou respectively.
T57 2249-2456 Sentence denotes Note that the mutation of the amino acid S to F keeps the R-group property unchanged (i.e. hydrophobic to hydrophilic) while that of the amino acid S to C changes the R-group from Hydrophilic to Hydrophobic.
T58 2457-2528 Sentence denotes This would possibly make changes in protein functions and interactions.
T59 2529-2592 Sentence denotes Table 1 Non- synonymous mutation in the E-protein of SARS-CoV2.
T60 2593-2650 Sentence denotes Protein-ID Geo-location Mutation Domain Change of R-group
T61 2651-2704 Sentence denotes QJA42107 USA: VA A36V TMDa Hydrophobic to Hydrophobic
T62 2705-2765 Sentence denotes QJQ84222 USA: KENNER, LA L26F TMD Hydrophobic to Hydrophobic
T63 2766-2822 Sentence denotes QHZ00381 South Korea L37H TMD Hydrophobic to Hydrophilic
T64 2823-2839 Sentence denotes QJS53352 Greece:
T65 2840-2882 Sentence denotes Athens L39M TMD Hydrophobic to Hydrophobic
T66 2883-2902 Sentence denotes QJR88103 Australia:
T67 2903-2954 Sentence denotes Victoria L73F C-terminus Hydrophobic to Hydrophobic
T68 2955-3014 Sentence denotes QKE45838 USA: CA P71L C-terminus Hydrophobic to Hydrophobic
T69 3015-3074 Sentence denotes QKE45886 USA: CA P71L C-terminus Hydrophobic to Hydrophobic
T70 3075-3134 Sentence denotes QKE45898 USA: CA P71L C-terminus Hydrophobic to Hydrophobic
T71 3135-3194 Sentence denotes QKE45910 USA: CA P71L C-terminus Hydrophobic to Hydrophobic
T72 3195-3254 Sentence denotes QJE38284 USA: CA P71L C-terminus Hydrophobic to Hydrophobic
T73 3255-3314 Sentence denotes QIU81527 USA: WA P71L C-terminus Hydrophobic to Hydrophobic
T74 3315-3328 Sentence denotes QKG87268 USA:
T75 3329-3385 Sentence denotes Massachusetts S68F C-terminus Hydrophobic to Hydrophobic
T76 3386-3399 Sentence denotes QKG88576 USA:
T77 3400-3456 Sentence denotes Massachusetts S68F C-terminus Hydrophobic to Hydrophobic
T78 3457-3472 Sentence denotes QKI36831 China:
T79 3473-3525 Sentence denotes Guangzhou D72Y C-terminus Hydrophilic to Hydrophobic
T80 3526-3541 Sentence denotes QKI36855 China:
T81 3542-3594 Sentence denotes Guangzhou S68C C-terminus Hydrophilic to Hydrophobic
T82 3595-3623 Sentence denotes a TMD: transmembrane domain.