LitCovid-sentences  

PMC:7335494 / 96717-99200 JSONTXT 11 Projects

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Id Subject Object Predicate Lexical cue
T574 0-96 Sentence denotes Metabolic disarray and inflammation are important factors in the pathogenesis of acute diseases.
T575 97-405 Sentence denotes COVID-19, severe respiratory disease, is an adverse clinical outcome of the ongoing severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic (Docea et al., 2020; Goumenou et al., 2020; Shi et al., 2020), and has recently been correlated to obesity-dependent inflammation (Petrakis et al., 2020).
T576 406-612 Sentence denotes Indeed, in its most severe form, it entails a bilateral interstitial pneumonia requiring intensive care unit (ICU) ventilation support and has concomitant high mortality rate due to and multi-organ failure.
T577 613-799 Sentence denotes Clinical reports have demonstrated that the most common comorbidities are CVD, hypertension and T2DM, age also being an important risk factor (Grasselli et al., 2020; Zhou et al., 2020).
T578 800-976 Sentence denotes Lifestyle-associated factors, such as smoking, have also been associated with rapid disease progression (Farsalinos et al., 2020; Mesnage et al., 2020; Tsatsakis et al., 2020).
T579 977-1086 Sentence denotes A recent US study indicates that obesity is an underappreciated risk factor for COVID-19 (Kass et al., 2020).
T580 1087-1313 Sentence denotes The authors found, in a cohort of 265 hospitalized patients, that age and the body-mass index (BMI) were inversely correlated with risk, hence indicating that younger obese patients were more likely to be admitted to hospital.
T581 1314-1482 Sentence denotes Kass et al. concluded that a higher prevalence of obesity in each population will result in a higher COVID-19 incidence in younger individuals than previously reported.
T582 1483-1640 Sentence denotes In addition to a mechanical impediment of ventilation, obesity was correlated with lower immune response to viral infection (Honce and Schultz-Cherry, 2019).
T583 1641-1782 Sentence denotes Moreover, besides obesity, metabolic disarray and inflammation were suggested to contribute to COVID-19 pathogenesis (Petrakis et al., 2020).
T584 1783-2095 Sentence denotes Indeed, specific fat-resident regulatory T cells (Treg) and enhancement of TH17 (T-cell sub-lineage)-biased immunity (Poutahidis et al., 2013; Winer et al., 2009) could be positively correlated to COVID-19 prevalence and increased mortality risk in obese individuals (Petrakis et al., 2020; Skalny et al., 2020).
T585 2096-2316 Sentence denotes The “obese” pattern of immune cells subtypes was correlated to increased secretion of pro-inflammatory mediators including IL-6, IL-23/IL-17, TNF-α and macrophage inflammatory protein-1α (Sumarac-Dumanovic et al., 2009).
T586 2317-2483 Sentence denotes Importantly, these inflammatory mediators were proved to disrupted tight junctions of the respiratory epithelium, which facilitates pathogen entry (Wittekindt, 2017).