LitCovid-sentences  

PMC:7324763 / 16097-18029 JSONTXT 13 Projects

Annnotations TAB TSV DIC JSON TextAE-old TextAE

Id Subject Object Predicate Lexical cue
T100 0-88 Sentence denotes Evasion of host immune responses is necessary for the successful propagation of a virus.
T101 89-248 Sentence denotes Mechanisms employed by CoVs to evade the immune response could provide insights into how the immune system, and NK cells in particular, responds to SARS-CoV-2.
T102 249-426 Sentence denotes CoVs have been shown to target components of the innate IFN response, employing non-structural proteins (nsps), structural proteins, and accessory proteins to achieve this goal.
T103 427-537 Sentence denotes Nsp16 methylates viral RNA therefore preventing recognition by MDA5 and dampening type I IFN production (116).
T104 538-771 Sentence denotes Nsps also suppress type I IFN responses via the inhibition of the transcription factor STAT1 mRNA transcription (nsp1) and deubiquitination of transcription factors like Interferon Regulatory Transcription Factor (IRF)3 (nsp3) (116).
T105 772-926 Sentence denotes Moreover, viral-encoded accessory proteins from SARS-CoV-1 open reading frame (ORF)3b and MERS-CoV ORF4a/4b also block IFN production and signaling (116).
T106 927-1031 Sentence denotes In addition, the MERS-CoV ORF6-encoded protein blocks p-STAT1 import, thus blocking IFN signaling (116).
T107 1032-1319 Sentence denotes Finally, the structural M protein of MERS-CoV (27) physically sequesters kinase proteins RIG-I, TBK1, IKKe, and TRAF3 and the SARS-CoV-1 N protein inhibits Activator Protein (AP)-1 signaling, protein kinase R function, and NFκB activation, all of which act to impede IFN responses (117).
T108 1320-1477 Sentence denotes In vivo murine studies report young mice rapidly clear SARS-CoV-1 infection, while old mice do not and that this discrepancy is due to a delay in type I IFN.
T109 1478-1596 Sentence denotes Furthermore, early administration of IFN-β induces a stronger immune response and reduces mortality in old mice (118).
T110 1597-1775 Sentence denotes Since type I IFNs are critical for NK cell activation and effector functions, it is possible that NK cell-mediated clearance of SARS-CoV-2 is being subverted by these mechanisms.
T111 1776-1932 Sentence denotes Further research into the role of NK cells in CoV clearance and potential immune evasion mechanisms are necessary to inform therapeutic development and use.