Id |
Subject |
Object |
Predicate |
Lexical cue |
T184 |
0-89 |
Sentence |
denotes |
Multiscale Embedded Correlation Networks to Uncover Pathologically Relevant Lipid Modules |
T185 |
90-254 |
Sentence |
denotes |
Co-regulated genes often display similar patterns of gene expression, which translates to strong correlations between their gene expression levels (Williams, 2015). |
T186 |
255-572 |
Sentence |
denotes |
Under the same analogy, strong correlations between lipid levels can imply that these lipids lie along a common metabolic pathway and are co-regulated, and changing correlation patterns between lipid-pairs in disease compared to healthy states can potentially indicate pathologically relevant metabolic dysregulation. |
T187 |
573-834 |
Sentence |
denotes |
We had previously shown in a cohort of antecedent diabetes that such a systems approach to interrogate lipidomics data based on differential correlations can sieve out pathway aberrations even before actual changes in metabolite levels set in (Lu et al., 2019). |
T188 |
835-1137 |
Sentence |
denotes |
Thus, in order to decipher lipid pathway dysregulation at early stages of infection, we then looked for pathologically relevant lipid modules in mild COVID-19 relative to healthy controls using MEGENA R to construct networks from differentially correlated lipid pairs calculated via the R package DGCA. |
T189 |
1138-1220 |
Sentence |
denotes |
Only differential correlations with empirical p < 0.05 were displayed (Figure 4 ). |
T190 |
1221-1316 |
Sentence |
denotes |
Four notable modules in the global network were circled and enlarged for emphasized discussion. |
T191 |
1317-1422 |
Sentence |
denotes |
Figure 4 Differential Correlation Analyses of Plasma Lipids in Mild COVID-19 Relative to Healthy Controls |
T192 |
1423-1651 |
Sentence |
denotes |
Multiscale embedded correlation network analysis illustrates the differential correlation of lipids in mild COVID-19 relative to healthy controls to reveal changes in lipid metabolic pathways upon early stage of viral infection. |
T193 |
1652-1747 |
Sentence |
denotes |
Only lipid pairs with significant differential correlations (empirical p < 0.05) were included. |
T194 |
1748-1945 |
Sentence |
denotes |
Sign/sign indicates direction and strength of correlation in control/mild COVID-19, and number that follows indicates number of lipid pairs in the global networks exhibiting this pattern of change. |
T195 |
1946-2334 |
Sentence |
denotes |
For instance, red line +/++ 1 in the upper legend of the global networks indicates that correlation between two connected lipid pairs was positive (+) in controls, and the correlation became even more strongly positive (++) in mild COVID-19 patients, as defined by statistically significant (p < 0.05) increase in correlation coefficients between the lipid pair across the two conditions. |
T196 |
2335-2444 |
Sentence |
denotes |
A total of 1 lipid pair connected by red lines in the global network displayed this pattern of change (+/++). |
T197 |
2445-2510 |
Sentence |
denotes |
Blue line +/− : positive in controls → negative in mild COVID-19. |
T198 |
2511-2580 |
Sentence |
denotes |
Teal line +/0: positive in controls → insignificant in mild COVID-19. |
T199 |
2581-2662 |
Sentence |
denotes |
Gold line ++/+: strongly positive in controls → weaker positive in mild COVID-19. |
T200 |
2663-2758 |
Sentence |
denotes |
Purple line 0/−: insignificant correlation in controls → negative correlation in mild COVID-19. |
T201 |
2759-2852 |
Sentence |
denotes |
Gray line 0/+: insignificant correlation in controls → positive correlation in mild COVID-19. |
T202 |
2853-3595 |
Sentence |
denotes |
Four modules (I–IV) of biological interest were circled and expanded for better visual clarity. (I) Module with hub PS 34:1 connected to numerous PEs by teal lines, indicating PS-PE positive correlations in healthy controls were lost in mild COVID-19. (II) Module with hub BMP 38:5(18:1/20:4) connected to CEs by blue lines, indicating BMP-CE correlations became negative in mild COVID-19. (III) Module with GM3 d18:0/25:0 as hub connected to several PSs by blue and purple lines, indicating GM3-PS correlations became negative in mild COVID-19. (IV) Module with LysoPC 16:1 as the hub connected to numerous PUFA-PEs by blue lines, indicating lysoPC-PUFA-PE correlations changed from positive in healthy controls to negative in mild COVID-19. |
T203 |
3596-3781 |
Sentence |
denotes |
PS, phosphatidylserines; PE, phosphatidylethanolamines; BMP, bis(monoacylglycero)phosphates; CE, cholesteryl esters; GM3, monosiaolodihexosyl gangliosides; PUFA-PE, polyunsaturated PEs. |