LitCovid-sentences  

PMC:7307149 / 759-2240 JSONTXT 8 Projects

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Id Subject Object Predicate Lexical cue
T11 0-335 Sentence denotes Genetic variability across the three major histocompatibility complex (MHC) class I genes (human leukocyte antigen A [HLA-A], -B, and -C genes) may affect susceptibility to and severity of the disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for coronavirus disease 2019 (COVID-19).
T12 336-497 Sentence denotes We performed a comprehensive in silico analysis of viral peptide-MHC class I binding affinity across 145 HLA-A, -B, and -C genotypes for all SARS-CoV-2 peptides.
T13 498-625 Sentence denotes We further explored the potential for cross-protective immunity conferred by prior exposure to four common human coronaviruses.
T14 626-725 Sentence denotes The SARS-CoV-2 proteome was successfully sampled and was represented by a diversity of HLA alleles.
T15 726-956 Sentence denotes However, we found that HLA-B*46:01 had the fewest predicted binding peptides for SARS-CoV-2, suggesting that individuals with this allele may be particularly vulnerable to COVID-19, as they were previously shown to be for SARS (M.
T16 957-967 Sentence denotes Lin, H.-T.
T17 968-977 Sentence denotes Tseng, J.
T18 978-980 Sentence denotes A.
T19 981-995 Sentence denotes Trejaut, H.-L.
T20 996-1104 Sentence denotes Lee, et al., BMC Med Genet 4:9, 2003, https://bmcmedgenet.biomedcentral.com/articles/10.1186/1471-2350-4-9).
T21 1105-1341 Sentence denotes Conversely, we found that HLA-B*15:03 showed the greatest capacity to present highly conserved SARS-CoV-2 peptides that are shared among common human coronaviruses, suggesting that it could enable cross-protective T-cell-based immunity.
T22 1342-1481 Sentence denotes Finally, we reported global distributions of HLA types with potential epidemiological ramifications in the setting of the current pandemic.