LitCovid-sentences  

PMC:7307149 / 750-2843 JSONTXT 8 Projects

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Id Subject Object Predicate Lexical cue
T10 0-8 Sentence denotes ABSTRACT
T11 9-344 Sentence denotes Genetic variability across the three major histocompatibility complex (MHC) class I genes (human leukocyte antigen A [HLA-A], -B, and -C genes) may affect susceptibility to and severity of the disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for coronavirus disease 2019 (COVID-19).
T12 345-506 Sentence denotes We performed a comprehensive in silico analysis of viral peptide-MHC class I binding affinity across 145 HLA-A, -B, and -C genotypes for all SARS-CoV-2 peptides.
T13 507-634 Sentence denotes We further explored the potential for cross-protective immunity conferred by prior exposure to four common human coronaviruses.
T14 635-734 Sentence denotes The SARS-CoV-2 proteome was successfully sampled and was represented by a diversity of HLA alleles.
T15 735-965 Sentence denotes However, we found that HLA-B*46:01 had the fewest predicted binding peptides for SARS-CoV-2, suggesting that individuals with this allele may be particularly vulnerable to COVID-19, as they were previously shown to be for SARS (M.
T16 966-976 Sentence denotes Lin, H.-T.
T17 977-986 Sentence denotes Tseng, J.
T18 987-989 Sentence denotes A.
T19 990-1004 Sentence denotes Trejaut, H.-L.
T20 1005-1113 Sentence denotes Lee, et al., BMC Med Genet 4:9, 2003, https://bmcmedgenet.biomedcentral.com/articles/10.1186/1471-2350-4-9).
T21 1114-1350 Sentence denotes Conversely, we found that HLA-B*15:03 showed the greatest capacity to present highly conserved SARS-CoV-2 peptides that are shared among common human coronaviruses, suggesting that it could enable cross-protective T-cell-based immunity.
T22 1351-1490 Sentence denotes Finally, we reported global distributions of HLA types with potential epidemiological ramifications in the setting of the current pandemic.
T23 1491-1609 Sentence denotes IMPORTANCE Individual genetic variation may help to explain different immune responses to a virus across a population.
T24 1610-1758 Sentence denotes In particular, understanding how variation in HLA may affect the course of COVID-19 could help identify individuals at higher risk from the disease.
T25 1759-1798 Sentence denotes HLA typing can be fast and inexpensive.
T26 1799-1927 Sentence denotes Pairing HLA typing with COVID-19 testing where feasible could improve assessment of severity of viral disease in the population.
T27 1928-2093 Sentence denotes Following the development of a vaccine against SARS-CoV-2, the virus that causes COVID-19, individuals with high-risk HLA types could be prioritized for vaccination.