| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T19 |
0-12 |
Sentence |
denotes |
Introduction |
| T20 |
13-318 |
Sentence |
denotes |
Invasive pulmonary aspergillosis (IPA) is a well-recognized disease affecting immunocompromised individuals with prolonged neutropenia, inherited neutrophil disorders or T cell defects, with the risk depending on the patients’ underlying disease and the type and duration of immunosuppressive therapy [1]. |
| T21 |
319-620 |
Sentence |
denotes |
Patients at the highest risk of invasive aspergillosis (IA) include those undergoing intensive chemotherapy for acute leukemia (AL) or recipients of allogeneic cell transplantation (alloHCT) who develop severe graft-versus-host disease, for whom antifungal prophylaxis is currently recommended [2, 3]. |
| T22 |
621-740 |
Sentence |
denotes |
With changing treatment modalities, new risk groups continue to emerge, such as patients treated with ibrutinib [4, 5]. |
| T23 |
741-1003 |
Sentence |
denotes |
Although over the past four decades a link between influenza and IPA has been noted in single cases [6], recent cohort studies provide new insights into the epidemiology and clinical presentation of IPA in intensive care unit (ICU) patients with influenza [7–9]. |
| T24 |
1004-1370 |
Sentence |
denotes |
Patients presenting with influenza-associated pulmonary aspergillosis (IAPA) may have classic European Organization for Research and Treatment of Cancer (EORTC)/Mycosis Study Group Education and Research Consortium (MSGERC)-defined host factors [10], but a notable proportion of patients was deemed to be at low risk of IPA, including previously healthy individuals. |
| T25 |
1371-1536 |
Sentence |
denotes |
In addition, the clinical and radiological presentation was often atypical with radiological features that were not considered suggestive of invasive fungal disease. |
| T26 |
1537-1749 |
Sentence |
denotes |
As a consequence, we cannot classify these patients according to existing consensus definitions, i.e., the EORTC/MSGERC definitions and the AspICU algorithm for classification of IPA patients in the ICU [10, 11]. |
| T27 |
1750-1971 |
Sentence |
denotes |
We therefore set out to discuss current insights into the epidemiology, pathogenesis, diagnosis and management of IAPA and to propose case definitions that can facilitate homogeneity and comparability in clinical studies. |
