LitCovid-sentences  

PMC:7283670 / 14243-16812 JSONTXT 10 Projects

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Id Subject Object Predicate Lexical cue
T109 0-82 Sentence denotes 2.4 Myocardial, gastrointestinal, and renal symptoms: homeostasis of electrolytes
T110 83-327 Sentence denotes An essential player in maintenance of electrolyte balance and blood pressure, ACE2 is regarded by many as the principal counter‐regulatory arm in the axis of renin–angiotensin‐aldosterone system (RAAS; Santos, Ferreira, & Simões e Silva, 2008).
T111 328-366 Sentence denotes Upon infection, SARS‐CoV‐2 binds ACE2.
T112 367-466 Sentence denotes This results in degradation of ACE2, which subsequently dampens the counter‐effect of ACE2 on RAAS.
T113 467-612 Sentence denotes The final effect of ACE2 in an otherwise healthy adult is to increase reabsorption of sodium and the reciprocal excretion of potassium ions (K+).
T114 613-732 Sentence denotes The concomitant re‐uptake of water with sodium reabsorption prompts an increase in blood pressure (Weir & Rolfe, 2010).
T115 733-846 Sentence denotes Potassium is the predominant intracellular ion, that is majorly involved in regulation of cell membrane polarity.
T116 847-938 Sentence denotes Too low levels of K+ in blood, known as hypokalemia, can result in cellular hyper‐polarity.
T117 939-1098 Sentence denotes A hyper‐polarized cell membrane tends to be depolarized faster than normal, causing aberrancy in the function of cardiac cells (Bielecka‐Dabrowa et al., 2012).
T118 1099-1244 Sentence denotes In a recent cohort study, patients diagnosed with COVID‐19 were categorized into three groups: severe hypokalemia, hypokalemia, and normokalemia.
T119 1245-1334 Sentence denotes The study reported that 93% of patients with a severe clinical condition had hypokalemia.
T120 1335-1483 Sentence denotes Scientists did not find a direct link between gastrointestinal symptoms and hypokalemia among 108 patients with both severe or moderate hypokalemia.
T121 1484-1733 Sentence denotes Further investigations established an association between parameters such as body temperature, creatine kinase (CK), creatine kinase myocardial band (CK‐MB), lactate dehydrogenase (LDH), and C‐reactive protein (CRP) with the severity of hypokalemia.
T122 1734-1853 Sentence denotes Reportedly, hypokalemia was most often observed with patients who had elevated levels of serum CK, CK‐MB, LDH, and CRP.
T123 1854-1941 Sentence denotes Potassium (K+) loss in the urine was determined to be the primary cause of hypokalemia.
T124 1942-1997 Sentence denotes Hypokalemia requires strenuous efforts to be corrected.
T125 1998-2092 Sentence denotes This is chiefly due to the incessant loss of K+ in the urine, as a result of ACE2 degradation.
T126 2093-2251 Sentence denotes In the case of COVID‐19‐associated hypokalemia, however, the patients seemed to respond well to potassium supplements when the critical phase had passed [49].
T127 2252-2376 Sentence denotes Therefore, one should consider the impact of hypokalemia in COVID‐19 morbidity, and its effect on the outcomes of treatment.
T128 2377-2569 Sentence denotes This is a condition that must be carefully addressed for, as patients with COVID‐19 are more inclined to develop dysfunctions in heart, lungs, and other vital organs (Li, Hu, Su, & Dai, 2020).