Id |
Subject |
Object |
Predicate |
Lexical cue |
T13 |
0-145 |
Sentence |
denotes |
Between March 12th and April 25th 2020, 34 COVID-19 patients were admitted to our ICU, of whom 20 (59%) required invasive mechanical ventilation. |
T14 |
146-219 |
Sentence |
denotes |
Seven of these ventilated patients (35%) were suspected of IPA (Table 1). |
T15 |
220-294 |
Sentence |
denotes |
Median age in our patient cohort was 66 (interquartile range 56–77) years. |
T16 |
295-350 |
Sentence |
denotes |
Underlying comorbidities were primarily cardiovascular. |
T17 |
351-394 |
Sentence |
denotes |
Only three patients were immunocompromised. |
T18 |
395-725 |
Sentence |
denotes |
One patient received chronic corticosteroid treatment for pemphigus foliaceous, one patient was HIV-positive (CD4 count > 250; viral load < 20 copies, treated with antiretrovirals [lamivudine/tenofovir/nevirapine]) and one patient had been treated for acute myeloid leukaemia 8 years ago and had developed IPA during chemotherapy. |
T19 |
726-815 |
Sentence |
denotes |
All patients were intubated and mechanically ventilated due to severe COVID-19 pneumonia. |
T20 |
816-851 |
Sentence |
denotes |
Table 1 Patients with suspected IPA |
T21 |
852-1179 |
Sentence |
denotes |
Patient ID Sex (M/F) Age Medical history Time between COVID-19 symptoms and ICU admission (days) Time between COVID-19 symptoms and intubation (days) Time between intubation and first finding of IPA (days) First BAL galactomannan index Peak BAL galactomannan index First serum galactomannan index Peak serum galactomannan index |
T22 |
1180-1220 |
Sentence |
denotes |
1 M 86 Hyperchol 7 7 9 N/A N/A 0.10 0.10 |
T23 |
1221-1274 |
Sentence |
denotes |
2 M 38 Obesity, hyperchol 9 9 6 2.40 > 2.80 0.30 0.30 |
T24 |
1275-1311 |
Sentence |
denotes |
3 M 62 DM 7 7 16 0.72 2.00 0.20 0.20 |
T25 |
1312-1375 |
Sentence |
denotes |
4 M 73 DM, obesity, AHT, hyperchol 9 10 5 2.65 > 2.80 0.10 0.10 |
T26 |
1376-1443 |
Sentence |
denotes |
5 M 77 DM, CKD, AHT, pemphigus foliaceus 9 10 2 2.79 2.79 0.10 0.10 |
T27 |
1444-1497 |
Sentence |
denotes |
6 M 55 HIV, AHT, hyperchol 8 9 13 0.69 0.69 0.18 0.80 |
T28 |
1498-1544 |
Sentence |
denotes |
7 M 75 AML, IPA (2012) 3 3 8 2.63 2.63 N/A N/A |
T29 |
1545-1700 |
Sentence |
denotes |
Patient ID Sex (M/F) Age Medical history First positive culture CT scan Histological examinationa IPA diagnosis AspICU algorithm Antifungal therapy Outcome |
T30 |
1701-1781 |
Sentence |
denotes |
1 M 86 Hyperchol A. flavus (ETA) No scan available N/A – – None Died, ICU day 10 |
T31 |
1782-1906 |
Sentence |
denotes |
2 M 38 Obesity, hyperchol A. fumigatus (BAL) + Positive Proven Absolute Voriconazole, isavuconazole Alive on MV, ICU day 28b |
T32 |
1907-2008 |
Sentence |
denotes |
3 M 62 DM A. fumigatus (BAL) No scan available Positive Proven Absolute Voriconazole Died, ICU day 20 |
T33 |
2009-2143 |
Sentence |
denotes |
4 M 73 DM, obesity, AHT, hyperchol A. fumigatus (BAL) No scan available Positive Proven Absolute Voriconazole Alive on MV, ICU day 24b |
T34 |
2144-2284 |
Sentence |
denotes |
5 M 77 DM, CKD, AHT, pemphigus foliaceus A. fumigatus (BAL) No scan available Positive Proven Absolute Voriconazole Alive on MV, ICU day 21b |
T35 |
2285-2394 |
Sentence |
denotes |
6 M 55 HIV, AHT, hyperchol Negative No scan available Negative – Voriconazole, isavuconazole Died, ICU day 27 |
T36 |
2395-2489 |
Sentence |
denotes |
7 M 75 AML, IPA (2012) A. fumigatus (BAL) No scan available N/A – Voriconazole Died, ICU day 8 |
T37 |
2490-2584 |
Sentence |
denotes |
CKD chronic kidney disease, AML acute myeloid leukaemia, IPA invasive pulmonary aspergillosis. |
T38 |
2585-2794 |
Sentence |
denotes |
N/A no sample available, Hyperchol hypercholesterolaemia, AHT arterial hypertension, DM diabetes mellitus, BAL bronchoalveolar lavage, ETA endotracheal aspirate, MV mechanical ventilation arterial hypertension |
T39 |
2795-2871 |
Sentence |
denotes |
aAnatomopathological examination of tissue samples obtained via bronchoscopy |
T40 |
2872-2895 |
Sentence |
denotes |
bAt the time of writing |